7REG
DfrA1 complexed with NADPH and 4'-chloro-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-[1,1'-biphenyl]-4-carboxamide (UCP1228)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Dihydrofolate reductase type 1 | polymer | 157 | 17592.0 | 2 | UniProt (P00382) Pfam (PF00186) In PDB | Escherichia coli | Dihydrofolate reductase type I,Trimethoprim resistance protein |
| 2 | A, B | 4'-chloro-3'-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl][1,1'-biphenyl]-4-carboxamide | non-polymer | 419.9 | 2 | Chemie (4SI) | |||
| 3 | A, B | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 4 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35184.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 2366.7 | |
| All* | Total formula weight | 37550.7 |
