7R3Y
The crystal structure of the V426L variant of Pol2CORE in complex with DNA and an incoming nucleotide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, B) | DNA polymerase epsilon catalytic subunit | polymer | 1186 | 136725.2 | 2 | UniProt (A0A7I9C3S1) Pfam (PF03104) Pfam (PF22634) UniProt (by SIFTS) (P21951) | Saccharomyces cerevisiae (baker's yeast) | |
| 2 | B, E (P, C) | DNA Primer | polymer | 11 | 3293.2 | 2 | synthetic construct | ||
| 3 | C (T) | DNA Template | polymer | 16 | 4905.2 | 1 | synthetic construct | ||
| 4 | F (D) | DNA Template | polymer | 16 | 4889.2 | 1 | synthetic construct | ||
| 5 | G, J (A, B) | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE | non-polymer | 491.2 | 2 | Chemie (DTP) | |||
| 6 | H, I, K, L (A, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 7 | M, N, O (A, T, B) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 1186 (UniProt: A0A7I9C3S1)
| PDB | External Database | Details |
|---|---|---|
| Leu 426 | Val 426 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 289831.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1142.7 | |
| All* | Total formula weight | 290973.8 |
