7R2V
Structure of nsp14 from SARS-CoV-2 in complex with SAH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proofreading exoribonuclease nsp14 | polymer | 524 | 59356.9 | 2 | UniProt (P0DTD1) Pfam (PF06471) | Severe acute respiratory syndrome coronavirus 2 | ExoN,Guanine-N7 methyltransferase,Non-structural protein 14,nsp14 |
| 2 | C, L (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 3 | D, K, M, N (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 4 | E (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 5 | F, G, H, I, J... (A, B) | ZINC ION | non-polymer | 65.4 | 9 | Chemie (ZN) | |||
| 6 | S, T (A, B) | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 524 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ala 90 | Asp 6015 | engineered mutation |
| Ala 92 | Glu 6017 | engineered mutation |
| Ala 103 | Thr 6028 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 118713.9 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1904.1 | |
| All* | Total formula weight | 120618.0 |
