7R0C
Structure of the AVP-V2R-arrestin2-ScFv30 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Vasopressin V2 receptor | polymer | 378 | 41532.4 | 1 | UniProt (P30518) Pfam (PF00001) In PDB | Homo sapiens (human) | V2R,AVPR V2,Antidiuretic hormone receptor,Renal-type arginine vasopressin receptor |
| 2 | B | AVP | polymer | 10 | 1086.2 | 1 | Pfam (PF00220) UniProt (by SIFTS) (P01185) In PDB | Homo sapiens | |
| 3 | C | Arrestin2 | polymer | 424 | 47164.6 | 1 | UniProt (P49407) Pfam (PF00339) Pfam (PF02752) In PDB | Homo sapiens (human) | |
| 4 | D | ScFv30 | polymer | 284 | 30070.0 | 1 | synthetic construct |
Sequence modifications
A: 4 - 371 (UniProt: P30518)
C: 2 - 382 (UniProt: P49407)
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | expression tag |
| Pro -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Lys -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Asp 1 | - | expression tag |
| Asp 2 | - | expression tag |
| Ala 3 | - | expression tag |
| Gln 22 | Asn 22 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -41 | - | initiating methionine |
| Gly -40 | - | expression tag |
| Ala -39 | - | expression tag |
| Ser -38 | - | expression tag |
| Trp -37 | - | expression tag |
| Ser -36 | - | expression tag |
| His -35 | - | expression tag |
| Pro -34 | - | expression tag |
| Gln -33 | - | expression tag |
| Phe -32 | - | expression tag |
| Glu -31 | - | expression tag |
| Lys -30 | - | expression tag |
| Gly -29 | - | expression tag |
| Gly -28 | - | expression tag |
| Gly -27 | - | expression tag |
| Ser -26 | - | expression tag |
| Gly -25 | - | expression tag |
| Gly -24 | - | expression tag |
| Gly -23 | - | expression tag |
| Ser -22 | - | expression tag |
| Gly -21 | - | expression tag |
| Gly -20 | - | expression tag |
| Ser -19 | - | expression tag |
| Ser -18 | - | expression tag |
| Ala -17 | - | expression tag |
| Trp -16 | - | expression tag |
| Ser -15 | - | expression tag |
| His -14 | - | expression tag |
| Pro -13 | - | expression tag |
| Gln -12 | - | expression tag |
| Phe -11 | - | expression tag |
| Glu -10 | - | expression tag |
| Lys -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Glu -7 | - | expression tag |
| Val -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Gln -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 119853.3 | |
| All* | Total formula weight | 119853.3 |
