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7R0C

Structure of the AVP-V2R-arrestin2-ScFv30 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001992biological_processregulation of systemic arterial blood pressure by vasopressin
A0003084biological_processpositive regulation of systemic arterial blood pressure
A0003092biological_processrenal water retention
A0004930molecular_functionG protein-coupled receptor activity
A0005000molecular_functionvasopressin receptor activity
A0005515molecular_functionprotein binding
A0005768cellular_componentendosome
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007190biological_processactivation of adenylate cyclase activity
A0007599biological_processhemostasis
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0010628biological_processpositive regulation of gene expression
A0016020cellular_componentmembrane
A0021537biological_processtelencephalon development
A0030139cellular_componentendocytic vesicle
A0030669cellular_componentclathrin-coated endocytic vesicle membrane
A0032870biological_processcellular response to hormone stimulus
A0034097biological_processresponse to cytokine
A0035811biological_processnegative regulation of urine volume
A0038023molecular_functionsignaling receptor activity
A0042277molecular_functionpeptide binding
A0045777biological_processpositive regulation of blood pressure
A0045907biological_processpositive regulation of vasoconstriction
A0048471cellular_componentperinuclear region of cytoplasm
A1902533biological_processpositive regulation of intracellular signal transduction
B0005185molecular_functionneurohypophyseal hormone activity
B0005576cellular_componentextracellular region
C0000139cellular_componentGolgi membrane
C0000785cellular_componentchromatin
C0001664molecular_functionG protein-coupled receptor binding
C0001934biological_processpositive regulation of protein phosphorylation
C0002031biological_processG protein-coupled receptor internalization
C0002092biological_processpositive regulation of receptor internalization
C0003713molecular_functiontranscription coactivator activity
C0004402molecular_functionhistone acetyltransferase activity
C0004857molecular_functionenzyme inhibitor activity
C0005096molecular_functionGTPase activator activity
C0005159molecular_functioninsulin-like growth factor receptor binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005905cellular_componentclathrin-coated pit
C0006357biological_processregulation of transcription by RNA polymerase II
C0006511biological_processubiquitin-dependent protein catabolic process
C0007165biological_processsignal transduction
C0007601biological_processvisual perception
C0009968biological_processnegative regulation of signal transduction
C0015031biological_processprotein transport
C0016567biological_processprotein ubiquitination
C0016604cellular_componentnuclear body
C0030659cellular_componentcytoplasmic vesicle membrane
C0031143cellular_componentpseudopodium
C0031397biological_processnegative regulation of protein ubiquitination
C0031410cellular_componentcytoplasmic vesicle
C0031625molecular_functionubiquitin protein ligase binding
C0031701molecular_functionangiotensin receptor binding
C0032088biological_processnegative regulation of NF-kappaB transcription factor activity
C0032715biological_processnegative regulation of interleukin-6 production
C0032717biological_processnegative regulation of interleukin-8 production
C0035025biological_processpositive regulation of Rho protein signal transduction
C0042995cellular_componentcell projection
C0043149biological_processstress fiber assembly
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0045746biological_processnegative regulation of Notch signaling pathway
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C1990763molecular_functionarrestin family protein binding
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASSyMILAMTLDRHRaI
ChainResidueDetails
AALA125-ILE141

site_idPS00264
Number of Residues9
DetailsNEUROHYPOPHYS_HORM Neurohypophysial hormones signature. CYFqNCPrG
ChainResidueDetails
BCYS1-GLY9

site_idPS00295
Number of Residues19
DetailsARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL
ChainResidueDetails
CPHE61-LEU79

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Important for agonist activity on V1aR/AVPR1A => ECO:0000269|PubMed:18174156
ChainResidueDetails
BGLY9
CMET255
CLYS324
CLYS326

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Glycine amide => ECO:0000269|PubMed:13591312
ChainResidueDetails
BGLY9
AASP136-PRO159
AILE221-ARG271
ASER329-SER371

site_idSWS_FT_FI3
Number of Residues20
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
AILE78-ALA98

site_idSWS_FT_FI4
Number of Residues47
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ATRP99-ARG113
AARG181-TRP200
AALA294-VAL308

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
AALA114-LEU135

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
AVAL160-GLN180

site_idSWS_FT_FI7
Number of Residues19
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
AGLY201-GLY220

site_idSWS_FT_FI8
Number of Residues21
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
AMET272-TRP293

site_idSWS_FT_FI9
Number of Residues19
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
ALEU309-PHE328

site_idSWS_FT_FI10
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:9224808
ChainResidueDetails
ACYS341
ACYS342

site_idSWS_FT_FI11
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AGLN22

222415

PDB entries from 2024-07-10

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