Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7R0C

Structure of the AVP-V2R-arrestin2-ScFv30 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001992biological_processregulation of systemic arterial blood pressure by vasopressin
A0003084biological_processpositive regulation of systemic arterial blood pressure
A0003092biological_processrenal water retention
A0004930molecular_functionG protein-coupled receptor activity
A0005000molecular_functionvasopressin receptor activity
A0005515molecular_functionprotein binding
A0005768cellular_componentendosome
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007190biological_processactivation of adenylate cyclase activity
A0007599biological_processhemostasis
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0010628biological_processpositive regulation of gene expression
A0016020cellular_componentmembrane
A0021537biological_processtelencephalon development
A0030139cellular_componentendocytic vesicle
A0030669cellular_componentclathrin-coated endocytic vesicle membrane
A0032870biological_processcellular response to hormone stimulus
A0034097biological_processresponse to cytokine
A0035811biological_processnegative regulation of urine volume
A0038023molecular_functionsignaling receptor activity
A0045777biological_processpositive regulation of blood pressure
A0045907biological_processpositive regulation of vasoconstriction
A0048471cellular_componentperinuclear region of cytoplasm
A0070295biological_processrenal water absorption
A1902533biological_processpositive regulation of intracellular signal transduction
B0005185molecular_functionneurohypophyseal hormone activity
B0005576cellular_componentextracellular region
C0000139cellular_componentGolgi membrane
C0000785cellular_componentchromatin
C0001664molecular_functionG protein-coupled receptor binding
C0001678biological_processintracellular glucose homeostasis
C0001934biological_processpositive regulation of protein phosphorylation
C0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
C0002031biological_processG protein-coupled receptor internalization
C0002092biological_processpositive regulation of receptor internalization
C0003713molecular_functiontranscription coactivator activity
C0004402molecular_functionhistone acetyltransferase activity
C0004857molecular_functionenzyme inhibitor activity
C0005096molecular_functionGTPase activator activity
C0005159molecular_functioninsulin-like growth factor receptor binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005905cellular_componentclathrin-coated pit
C0006357biological_processregulation of transcription by RNA polymerase II
C0006511biological_processubiquitin-dependent protein catabolic process
C0007165biological_processsignal transduction
C0007166biological_processcell surface receptor signaling pathway
C0007600biological_processsensory perception
C0009968biological_processnegative regulation of signal transduction
C0010613biological_processpositive regulation of cardiac muscle hypertrophy
C0015031biological_processprotein transport
C0016567biological_processprotein ubiquitination
C0016604cellular_componentnuclear body
C0019899molecular_functionenzyme binding
C0030659cellular_componentcytoplasmic vesicle membrane
C0030666cellular_componentendocytic vesicle membrane
C0031143cellular_componentpseudopodium
C0031397biological_processnegative regulation of protein ubiquitination
C0031410cellular_componentcytoplasmic vesicle
C0031625molecular_functionubiquitin protein ligase binding
C0031701molecular_functionangiotensin receptor binding
C0032088biological_processnegative regulation of NF-kappaB transcription factor activity
C0032715biological_processnegative regulation of interleukin-6 production
C0032717biological_processnegative regulation of interleukin-8 production
C0035025biological_processpositive regulation of Rho protein signal transduction
C0043149biological_processstress fiber assembly
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0045746biological_processnegative regulation of Notch signaling pathway
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0060090molecular_functionmolecular adaptor activity
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C1902533biological_processpositive regulation of intracellular signal transduction
C1990763molecular_functionarrestin family protein binding
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASSyMILAMTLDRHRaI
ChainResidueDetails
AALA125-ILE141
site_idPS00264
Number of Residues9
DetailsNEUROHYPOPHYS_HORM Neurohypophysial hormones signature. CYFqNCPrG
ChainResidueDetails
BCYS1-GLY9
site_idPS00295
Number of Residues19
DetailsARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL
ChainResidueDetails
CPHE61-LEU79
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues13
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues28
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"9224808","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues41
DetailsRegion: {"description":"Interaction with CHRM2","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues11
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BWG8","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

PDB statisticsPDBj update infoContact PDBjnumon