7QIE
Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an allosteric inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | polymer | 363 | 42017.9 | 4 | UniProt (Q8TBX8) Pfam (PF01504) | Homo sapiens (human) | Phosphatidylinositol 5-phosphate 4-kinase type II gamma,PI(5)P 4-kinase type II gamma,PIP4KII-gamma |
| 2 | E, F, G, H (A, B, C, D) | 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-4-amine | non-polymer | 357.5 | 4 | Chemie (DVF) PubChem (163321784) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 199 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 32 - 421 (UniProt: Q8TBX8)
| PDB | External Database | Details |
|---|---|---|
| Met 17 | - | initiating methionine |
| Gly 18 | - | expression tag |
| His 19 | - | expression tag |
| His 20 | - | expression tag |
| His 21 | - | expression tag |
| His 22 | - | expression tag |
| His 23 | - | expression tag |
| His 24 | - | expression tag |
| Glu 25 | - | expression tag |
| Asn 26 | - | expression tag |
| Leu 27 | - | expression tag |
| Tyr 28 | - | expression tag |
| Phe 29 | - | expression tag |
| Gln 30 | - | expression tag |
| Gly 31 | - | expression tag |
| - | Ala 300 | deletion |
| - | Pro 301 | deletion |
| - | Val 302 | deletion |
| - | Arg 303 | deletion |
| - | Glu 304 | deletion |
| - | Asp 305 | deletion |
| - | Glu 306 | deletion |
| - | Ser 307 | deletion |
| - | Glu 308 | deletion |
| - | Val 309 | deletion |
| - | Asp 310 | deletion |
| - | Gly 311 | deletion |
| - | Asp 312 | deletion |
| - | Cys 313 | deletion |
| - | Ser 314 | deletion |
| - | Leu 315 | deletion |
| - | Thr 316 | deletion |
| - | Gly 317 | deletion |
| - | Pro 318 | deletion |
| - | Pro 319 | deletion |
| - | Ala 320 | deletion |
| - | Leu 321 | deletion |
| - | Val 322 | deletion |
| - | Gly 323 | deletion |
| - | Ser 324 | deletion |
| - | Tyr 325 | deletion |
| - | Gly 326 | deletion |
| - | Thr 327 | deletion |
| - | Ser 328 | deletion |
| - | Pro 329 | deletion |
| - | Glu 330 | deletion |
| - | Gly 331 | deletion |
| - | Ile 332 | deletion |
| - | Gly 333 | deletion |
| - | Gly 334 | deletion |
| - | Tyr 335 | deletion |
| - | Ile 336 | deletion |
| - | His 337 | deletion |
| - | Ser 338 | deletion |
| - | His 339 | deletion |
| - | Arg 340 | deletion |
| - | Pro 341 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 168071.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1429.8 | |
| All* | Total formula weight | 169501.5 |
