7QHG
LIM domain kinase 2 (LIMK2) in complex with TH-470
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | LIM domain kinase 2 | polymer | 305 | 34799.7 | 2 | UniProt (P53671) Pfam (PF07714) | Homo sapiens (human) | LIMK-2 |
| 2 | C, G (A, B) | 2-(2-methylpropanoylamino)-~{N}-[2-[(phenylmethyl)-[4-(phenylsulfamoyl)phenyl]carbonyl-amino]ethyl]-1,3-thiazole-5-carboxamide | non-polymer | 605.7 | 2 | Chemie (T3B) | |||
| 3 | D, E, F, H, I (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 4 | J, K (A, B) | water | water | 18.0 | 379 | Chemie (HOH) |
Sequence modifications
A, B: 330 - 632 (UniProt: P53671)
| PDB | External Database | Details |
|---|---|---|
| Ser 328 | - | expression tag |
| Met 329 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69599.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1521.8 | |
| All* | Total formula weight | 71121.2 |
