7QE9

Human cationic trypsin (TRY1) complexed with serine protease inhibitor Kazal type 1 N34S (SPINK1 N34S)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Trypsin-1	polymer	224	24121.2	2	UniProt (P07477) Pfam (PF00089) In PDB	Homo sapiens (Human)	Beta-trypsin,Cationic trypsinogen,Serine protease 1,Trypsin I
2	D, C	Serine protease inhibitor Kazal-type 1	polymer	61	6714.6	2	UniProt (P00995) Pfam (PF00050) In PDB	Homo sapiens (Human)	Pancreatic secretory trypsin inhibitor,Tumor-associated trypsin inhibitor,TATI
3	A, D, C	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4		water	water		18.0	231	Chemie (HOH)

Sequence modifications

A, B: 24 - 247 (UniProt: P07477)

PDB	External Database	Details
Ala 200	Ser 200	engineered mutation

D, C: 24 - 79 (UniProt: P00995)

PDB	External Database	Details
Gly 19	-	expression tag
Pro 20	-	expression tag
Gly 21	-	expression tag
Tyr 22	-	expression tag
Leu 23	-	expression tag
Ser 34	Asn 34	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	61671.6
Non-Polymers*	Number of molecules	4
	Total formula weight	384.3
All*	Total formula weight	62055.8

*Water molecules are not included.