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7QE9

Human cationic trypsin (TRY1) complexed with serine protease inhibitor Kazal type 1 N34S (SPINK1 N34S)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0007586biological_processdigestion
A0008236molecular_functionserine-type peptidase activity
A0022617biological_processextracellular matrix disassembly
A0046872molecular_functionmetal ion binding
A0062023cellular_componentcollagen-containing extracellular matrix
A0072562cellular_componentblood microparticle
B0004252molecular_functionserine-type endopeptidase activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006508biological_processproteolysis
B0007586biological_processdigestion
B0008236molecular_functionserine-type peptidase activity
B0022617biological_processextracellular matrix disassembly
B0046872molecular_functionmetal ion binding
B0062023cellular_componentcollagen-containing extracellular matrix
B0072562cellular_componentblood microparticle
C0004866molecular_functionendopeptidase inhibitor activity
C0004867molecular_functionserine-type endopeptidase inhibitor activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0007263biological_processnitric oxide mediated signal transduction
C0010751biological_processnegative regulation of nitric oxide mediated signal transduction
C0030414molecular_functionpeptidase inhibitor activity
C0031667biological_processresponse to nutrient levels
C0045471biological_processresponse to ethanol
C0048240biological_processsperm capacitation
C0050679biological_processpositive regulation of epithelial cell proliferation
C0050732biological_processnegative regulation of peptidyl-tyrosine phosphorylation
C0060046biological_processregulation of acrosome reaction
C0070062cellular_componentextracellular exosome
C0071375biological_processcellular response to peptide hormone stimulus
C0090187biological_processpositive regulation of pancreatic juice secretion
C0090277biological_processpositive regulation of peptide hormone secretion
C0090281biological_processnegative regulation of calcium ion import
C2001256biological_processregulation of store-operated calcium entry
D0004866molecular_functionendopeptidase inhibitor activity
D0004867molecular_functionserine-type endopeptidase inhibitor activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0007263biological_processnitric oxide mediated signal transduction
D0010751biological_processnegative regulation of nitric oxide mediated signal transduction
D0030414molecular_functionpeptidase inhibitor activity
D0031667biological_processresponse to nutrient levels
D0045471biological_processresponse to ethanol
D0048240biological_processsperm capacitation
D0050679biological_processpositive regulation of epithelial cell proliferation
D0050732biological_processnegative regulation of peptidyl-tyrosine phosphorylation
D0060046biological_processregulation of acrosome reaction
D0070062cellular_componentextracellular exosome
D0071375biological_processcellular response to peptide hormone stimulus
D0090187biological_processpositive regulation of pancreatic juice secretion
D0090277biological_processpositive regulation of peptide hormone secretion
D0090281biological_processnegative regulation of calcium ion import
D2001256biological_processregulation of store-operated calcium entry
Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAGHC
ChainResidueDetails
AVAL59-CYS64

site_idPS00282
Number of Residues23
DetailsKAZAL_1 Kazal serine protease inhibitors family signature. CtkiyDpvCgTdgntYpneCvl.C
ChainResidueDetails
DCYS39-CYS61

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Reactive bond for trypsin => ECO:0000250|UniProtKB:P09036, ECO:0000255|PROSITE-ProRule:PRU00798
ChainResidueDetails
DLYS41
CLYS41
AALA200
BHIS63
BASP107
BALA200

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Necessary for sperm binding => ECO:0000250|UniProtKB:P09036
ChainResidueDetails
DTYR43
CTYR43
AVAL80
AGLU85
BGLU75
BASN77
BVAL80
BGLU85

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Required for specificity => ECO:0000250
ChainResidueDetails
AASP194
BASP194

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Sulfotyrosine => ECO:0000305|PubMed:17087724, ECO:0000305|PubMed:25010489
ChainResidueDetails
ATYR154
BTYR154

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PDB entries from 2024-07-24

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