7Q1H
Variant D312N of Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with the substrate OMP at 1.31 Angstrom resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Uridine 5'-monophosphate synthase | polymer | 258 | 28202.7 | 1 | UniProt (P11172) Pfam (PF00215) | Homo sapiens (Human) | UMP synthase |
| 2 | B (A) | OROTIDINE-5'-MONOPHOSPHATE | non-polymer | 368.2 | 1 | Chemie (OMP) | |||
| 3 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D (A) | PROLINE | non-polymer | 115.1 | 1 | Chemie (PRO) | |||
| 5 | E (A) | water | water | 18.0 | 327 | Chemie (HOH) |
Sequence modifications
A: 224 - 480 (UniProt: P11172)
| PDB | External Database | Details |
|---|---|---|
| Met 223 | - | initiating methionine |
| Asn 312 | Asp 312 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28202.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 579.4 | |
| All* | Total formula weight | 28782.1 |
