7Q0G
Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-49 and FI-3A Fabs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | Spike protein S1 | polymer | 210 | 23646.6 | 1 | UniProt (P0DTC2) Pfam (PF09408) | Severe acute respiratory syndrome coronavirus 2 | |
| 2 | B (H) | FI-3A Fab heavy chain | polymer | 222 | 23521.4 | 1 | Homo sapiens | ||
| 3 | C (L) | FI-3A Fab light chain | polymer | 214 | 23364.8 | 1 | Homo sapiens | ||
| 4 | D (B) | Beta-49 Fab light chain | polymer | 216 | 23566.1 | 1 | Homo sapiens | ||
| 5 | E (A) | Beta-49 Fab heavy chain | polymer | 223 | 23431.4 | 1 | Homo sapiens | ||
| 6 | F (C) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 1 | In PDB GlyTouCan (G42466VF) | |||
| 7 | AA, G, H, I, IA... (L, E, B, H, A) | GLYCEROL | non-polymer | 92.1 | 13 | Chemie (GOL) | |||
| 8 | BA, CA, K, L, LA... (L, E, B, A, H) | CHLORIDE ION | non-polymer | 35.5 | 14 | Chemie (CL) | |||
| 9 | DA, EA, FA, GA, HA... (L, E, B, H, A) | POTASSIUM ION | non-polymer | 39.1 | 14 | Chemie (K) | |||
| 10 | QA, RA, S (A, H) | D(-)-TARTARIC ACID | non-polymer | 150.1 | 3 | Chemie (TAR) | |||
| 11 | AB, BB, CB, YA, ZA (L, B, A, E, H) | water | water | 18.0 | 317 | Chemie (HOH) |
Sequence modifications
E: 333 - 526 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Met 319 | - | initiating methionine |
| Gly 320 | - | expression tag |
| Cys 321 | - | expression tag |
| Val 322 | - | expression tag |
| Ala 323 | - | expression tag |
| Glu 324 | - | expression tag |
| Thr 325 | - | expression tag |
| Gly 326 | - | expression tag |
| His 327 | - | expression tag |
| His 328 | - | expression tag |
| His 329 | - | expression tag |
| His 330 | - | expression tag |
| His 331 | - | expression tag |
| His 332 | - | expression tag |
| Asn 417 | Lys 417 | variant |
| Lys 484 | Glu 484 | variant |
| Tyr 501 | Asn 501 | variant |
| Lys 527 | - | expression tag |
| Lys 528 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 117530.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 894.8 | |
| Non-Polymers* | Number of molecules | 44 |
| Total formula weight | 2691.2 | |
| All* | Total formula weight | 121116.4 |
