7PVS
Crystal structure of the Abl SH3 domain V73E-A74S-S75R-G76T-D77E-G92N-Y93N-N94T-H95E mutant in presence of PEG 200
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase ABL1 | polymer | 59 | 6650.3 | 2 | UniProt (P00519) Pfam (PF00018) | Homo sapiens (Human) | Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine-protein kinase 1,Proto-oncogene c-Abl,p150 |
| 2 | C (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 3 | D (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | E, F, G (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | H (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | I (B) | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 1 | Chemie (P6G) | |||
| 7 | J, K (A, B) | water | water | 18.0 | 141 | Chemie (HOH) |
Sequence modifications
A, B: 63 - 120 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Gly 62 | - | expression tag |
| Glu 73 | Val 73 | engineered mutation |
| Ser 74 | Ala 74 | engineered mutation |
| Arg 75 | Ser 75 | engineered mutation |
| Thr 76 | Gly 76 | engineered mutation |
| Glu 77 | Asp 77 | engineered mutation |
| Asn 92 | Gly 92 | engineered mutation |
| Asn 93 | Tyr 93 | engineered mutation |
| Thr 94 | Asn 94 | engineered mutation |
| Glu 95 | His 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 13300.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 849.8 | |
| All* | Total formula weight | 14150.4 |
