7PRV
The glucocorticoid receptor in complex with fluticasone furoate, a PGC1a coactivator fragment and sgk 23bp
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glucocorticoid receptor | polymer | 393 | 44511.5 | 2 | UniProt (P04150) Pfam (PF00105) Pfam (PF00104) | Homo sapiens (Human) | GR,Nuclear receptor subfamily 3 group C member 1 |
| 2 | C (C) | DNA (5'-D(*TP*CP*GP*AP*CP*GP*GP*AP*CP*AP*AP*AP*AP*TP*GP*TP*TP*CP*TP*GP*TP*A)-3') | polymer | 23 | 7064.6 | 1 | Homo sapiens | ||
| 3 | D (D) | DNA (5'-D(*TP*AP*CP*AP*GP*AP*AP*CP*AP*TP*TP*TP*TP*GP*TP*CP*CP*GP*TP*CP*GP*A)-3') | polymer | 23 | 7015.5 | 1 | Homo sapiens | ||
| 4 | E (F) | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | polymer | 21 | 2261.6 | 1 | UniProt (Q9UBK2) | Homo sapiens | PGC-1-alpha,PPAR-gamma coactivator 1-alpha,PPARGC-1-alpha,Ligand effect modulator 6, PGC1a coactivator fragment |
| 5 | F, G, L, M (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 6 | H, I, K (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 7 | J, N (A, B) | (6alpha,11alpha,14beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoan drosta-1,4-dien-17-yl furan-2-carboxylate | non-polymer | 538.6 | 2 | Chemie (GW6) PubChem (20734893) PubChem (24775951) PubChem (24847878) PubChem (23658408) PubChem (57688088) PubChem (87073368) PubChem (87100177) PubChem (87237605) PubChem (87306813) PubChem (87354324) PubChem (87660673) PubChem (87872484) PubChem (87910174) PubChem (177323721) PubChem (89855669) PubChem (90788774) PubChem (87290238) PubChem (87629110) PubChem (89332779) PubChem (91885052) PubChem (117951645) PubChem (129460976) PubChem (9854489) PubChem (122667793) PubChem (138655017) PubChem (11432650) PubChem (142271975) PubChem (159932720) PubChem (129373344) PubChem (129460975) PubChem (135324388) PubChem (142271972) PubChem (142853504) PubChem (142853508) PubChem (143546011) PubChem (146158826) PubChem (168312334) PubChem (169445785) PubChem (172012977) PubChem (172873948) | |||
| 8 | O, P, Q (A, B, C) | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A, B: 385 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Ala 404 | Ser 404 | engineered mutation |
| Asp 517 | Asn 517 | engineered mutation |
| Met 571 | Val 571 | engineered mutation |
| Ser 602 | Phe 602 | engineered mutation |
| Asp 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 105364.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1525.0 | |
| All* | Total formula weight | 106889.6 |
