7PRV
The glucocorticoid receptor in complex with fluticasone furoate, a PGC1a coactivator fragment and sgk 23bp
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Glucocorticoid receptor | polymer | 393 | 44511.5 | 2 | UniProt (P04150) Pfam (PF00105) Pfam (PF00104) In PDB | Homo sapiens (Human) | GR,Nuclear receptor subfamily 3 group C member 1 |
2 | C | DNA (5'-D(*TP*CP*GP*AP*CP*GP*GP*AP*CP*AP*AP*AP*AP*TP*GP*TP*TP*CP*TP*GP*TP*A)-3') | polymer | 23 | 7064.6 | 1 | Homo sapiens | ||
3 | D | DNA (5'-D(*TP*AP*CP*AP*GP*AP*AP*CP*AP*TP*TP*TP*TP*GP*TP*CP*CP*GP*TP*CP*GP*A)-3') | polymer | 23 | 7015.5 | 1 | Homo sapiens | ||
4 | F | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | polymer | 21 | 2261.6 | 1 | UniProt (Q9UBK2) In PDB | Homo sapiens | PGC-1-alpha,PPAR-gamma coactivator 1-alpha,PPARGC-1-alpha,Ligand effect modulator 6, PGC1a coactivator fragment |
5 | A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
6 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
7 | A, B | (6alpha,11alpha,14beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoan drosta-1,4-dien-17-yl furan-2-carboxylate | non-polymer | 538.6 | 2 | Chemie (GW6) | |||
8 | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A, B: 385 - 777 (UniProt: P04150)
PDB | External Database | Details |
---|---|---|
Ala 404 | Ser 404 | engineered mutation |
Asp 517 | Asn 517 | engineered mutation |
Met 571 | Val 571 | engineered mutation |
Ser 602 | Phe 602 | engineered mutation |
Asp 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 105364.7 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1525.0 | |
All* | Total formula weight | 106889.6 |