7PP1
Crystal structure of the P2Y12 receptor in complex with the inverse agonist selatogrel.
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | AAA | P2Y purinoceptor 12,Soluble cytochrome b562,P2Y purinoceptor 12 | polymer | 466 | 53248.9 | 1 | UniProt (Q9H244) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) In PDB | Homo sapiens (Human) | P2Y12,ADP-glucose receptor,ADPG-R,P2T(AC),P2Y(AC),P2Y(cyc),P2Y12 platelet ADP receptor,P2Y(ADP),SP1999,Cytochrome b-562,P2Y12,ADP-glucose receptor,ADPG-R,P2T(AC),P2Y(AC),P2Y(cyc),P2Y12 platelet ADP receptor,P2Y(ADP),SP1999 |
2 | AAA | Selatogrel | non-polymer | 618.6 | 1 | Chemie (7Y5) | |||
3 | AAA | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
4 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
AAA: 2 - 223 (UniProt: Q9H244)
AAA: 1001 - 1106 (UniProt: P0ABE7)
AAA: 224 - 342 (UniProt: Q9H244)
PDB | External Database | Details |
---|---|---|
Asp -8 | - | expression tag |
Tyr -7 | - | expression tag |
Lys -6 | - | expression tag |
Asp -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Gly -1 | - | expression tag |
Ala 0 | - | expression tag |
Pro 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Trp 1007 | Met 29 | engineered mutation |
Ile 1102 | His 124 | engineered mutation |
Leu 1106 | Arg 128 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Asn 294 | Asp 294 | engineered mutation |
Gly 343 | - | expression tag |
Arg 344 | - | expression tag |
Pro 345 | - | expression tag |
Leu 346 | - | expression tag |
Glu 347 | - | expression tag |
Val 348 | - | expression tag |
Leu 349 | - | expression tag |
Phe 350 | - | expression tag |
Gln 351 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 53248.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1005.3 | |
All* | Total formula weight | 54254.2 |