7PP1
Crystal structure of the P2Y12 receptor in complex with the inverse agonist selatogrel.
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| AAA | 0004930 | molecular_function | G protein-coupled receptor activity |
| AAA | 0005506 | molecular_function | iron ion binding |
| AAA | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| AAA | 0007194 | biological_process | negative regulation of adenylate cyclase activity |
| AAA | 0007596 | biological_process | blood coagulation |
| AAA | 0009055 | molecular_function | electron transfer activity |
| AAA | 0016020 | cellular_component | membrane |
| AAA | 0020037 | molecular_function | heme binding |
| AAA | 0022900 | biological_process | electron transport chain |
| AAA | 0042597 | cellular_component | periplasmic space |
| AAA | 0045028 | molecular_function | G protein-coupled purinergic nucleotide receptor activity |
| AAA | 0046872 | molecular_function | metal ion binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=1 |
| Chain | Residue | Details |
| AAA | PHE28-PHE50 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 76 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| AAA | PHE51-ILE61 | |
| AAA | THR119-LYS142 | |
| AAA | PHE299-MET342 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 |
| Chain | Residue | Details |
| AAA | PHE62-LEU82 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 54 |
| Details | TOPO_DOM: Extracellular |
| Chain | Residue | Details |
| AAA | SER83-CYS97 | |
| AAA | THR163-VAL185 | |
| AAA | THR260-TYR278 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 |
| Chain | Residue | Details |
| AAA | GLN98-ILE118 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=4 |
| Chain | Residue | Details |
| AAA | ILE143-LEU162 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=5 |
| Chain | Residue | Details |
| AAA | TRP186-VAL207 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=6 |
| Chain | Residue | Details |
| AAA | VAL234-TYR259 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=7 |
| Chain | Residue | Details |
| AAA | VAL279-TYR298 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | BINDING: |
| Chain | Residue | Details |
| AAA | ARG93 | |
| AAA | LYS280 | |
| AAA | CYS97 | |
| AAA | TYR105 | |
| AAA | SER156 | |
| AAA | CYS175 | |
| AAA | HIS187 | |
| AAA | ASN191 | |
| AAA | ARG256 | |
| AAA | GLN263 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9EPX4 |
| Chain | Residue | Details |
| AAA | SER55 | |
| AAA | SER57 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| AAA | ASN6 | |
| AAA | ASN13 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| AAA | TRP1007 | |
| AAA | ILE1102 |
