7PHJ

LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	UDP-3-O-acyl-N-acetylglucosamine deacetylase	polymer	305	33995.9	1	UniProt (P0A725) Pfam (PF03331) In PDB	Escherichia coli (strain K12)	UDP-3-O-acyl-GlcNAc deacetylase,Protein EnvA,UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase
2	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	A	(2~{R},4~{R})-4-[[(2~{S},4~{S})-4-fluoranylpyrrolidin-2-yl]carbonylamino]-1-(2-methylpropanoyl)-~{N}-[[4-(2-phenylethynyl)phenyl]methyl]pyrrolidine-2-carboxamide	non-polymer		504.6	1	Chemie (7PX)
4		water	water		18.0	41	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33995.9
Non-Polymers*	Number of molecules	2
	Total formula weight	570.0
All*	Total formula weight	34565.9

*Water molecules are not included.