7PHJ

LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0005737	cellular_component	cytoplasm
A	0006796	biological_process	phosphate-containing compound metabolic process
A	0008270	molecular_function	zinc ion binding
A	0008759	molecular_function	obsolete UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A	0009245	biological_process	lipid A biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0019213	molecular_function	deacetylase activity
A	0019637	biological_process	organophosphate metabolic process
A	0046872	molecular_function	metal ion binding
A	0103117	molecular_function	UDP-3-O-acyl-N-acetylglucosamine deacetylase activity
A	1901135	biological_process	carbohydrate derivative metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00388, ECO:0000305|PubMed:15705580, ECO:0000305|PubMed:24108127

Chain	Residue	Details
A	HIS265

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00388, ECO:0000269|PubMed:24108127, ECO:0000269|PubMed:24117400

Chain	Residue	Details
A	HIS79
A	HIS238
A	ASP242

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