7PHE
Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-hydroxylase RdmB and 10-decarboxylase TamK
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB | polymer | 368 | 39982.4 | 2 | UniProt (Q06528) UniProt (I2N5E8) UniProt (Q54527) Pfam (PF00891) In PDB | Streptomyces peucetius | COMT,Anthracycline 4-O-methyltransferase,O-methyltransferase,15-demethoxy-epsilon-rhodomycin 10-hydroxylase,15-demethoxyaclacinomycin T |
2 | A, B | methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate | non-polymer | 412.4 | 2 | Chemie (VAK) | |||
3 | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 159 (UniProt: Q06528)
A, B: 160 - 169 (UniProt: I2N5E8)
A, B: 170 - 285 (UniProt: Q06528)
A, B: 286 - 300 (UniProt: Q54527)
A, B: 301 - 334 (UniProt: Q06528)
A, B: 335 - 347 (UniProt: I2N5E8)
A, B: 348 - 358 (UniProt: Q06528)
PDB | External Database | Details |
---|---|---|
Met -9 | - | initiating methionine |
Ala -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
Arg 0 | - | expression tag |
Ser 1 | - | expression tag |
A, B: 170 - 285 (UniProt: Q06528)
PDB | External Database | Details |
---|---|---|
Ala 189 | Gly 189 | engineered mutation |
Pro 190 | Lys 190 | engineered mutation |
A, B: 301 - 334 (UniProt: Q06528)
A, B: 335 - 347 (UniProt: I2N5E8)
A, B: 348 - 358 (UniProt: Q06528)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 79964.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 824.8 | |
All* | Total formula weight | 80789.6 |