7PEL

CryoEM structure of simian T-cell lymphotropic virus intasome in complex with PP2A regulatory subunit B56 gamma

Replaces:  6Z2Y

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, F, G (A, B, D, E)	Pol protein	polymer	301	33885.5	4	UniProt (Q4QY51) Pfam (PF02022) Pfam (PF00665) Pfam (PF00552)	Simian T-lymphotropic virus 1
2	C, H (C, F)	Isoform 3 of PC4 and SFRS1-interacting protein,Isoform Gamma-2 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	polymer	697	80394.7	2	UniProt (O75475) UniProt (Q13362) Pfam (PF00855) Pfam (PF01603)	Homo sapiens (Human)	PP2A B subunit isoform B'-gamma,PP2A B subunit isoform B56-gamma,PP2A B subunit isoform PR61-gamma,PP2A B subunit isoform R5-gamma,Renal carcinoma antigen NY-REN-29
3	D, I (K, M)	DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3')	polymer	30	9221.9	2		synthetic construct
4	E, J (L, N)	DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3')	polymer	28	8593.6	2		synthetic construct
5	K, L, M, N (A, B, D, E)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)

Sequence modifications

A, B, D, E: 1 - 297 (UniProt: Q4QY51)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag

C, F: -315 - 9 (UniProt: O75475)

PDB	External Database	Details
Ser -316	-	expression tag
Phe 10	-	linker

C, F: 11 - 380 (UniProt: Q13362)

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	331962.3
Non-Polymers*	Number of molecules	4
	Total formula weight	261.6
All*	Total formula weight	332224.0

*Water molecules are not included.