7PEE
Crystal structure of extracellular part of human Trop2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Tumor-associated calcium signal transducer 2 | polymer | 250 | 28381.3 | 4 | UniProt (P09758) Pfam (PF18635) Pfam (PF00086) Pfam (PF21283) In PDB | Homo sapiens (Human) | Cell surface glycoprotein Trop-2,Membrane component chromosome 1 surface marker 1,Pancreatic carcinoma marker protein GA733-1,Trop2EX |
2 | E, F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 2 | In PDB GlyTouCan (G21290RB) | |||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
4 | C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
5 | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 31 - 274 (UniProt: P09758)
PDB | External Database | Details |
---|---|---|
Gln 120 | Asn 120 | engineered mutation |
Gln 208 | Asn 208 | engineered mutation |
His 275 | - | expression tag |
His 276 | - | expression tag |
His 277 | - | expression tag |
His 278 | - | expression tag |
His 279 | - | expression tag |
His 280 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 113525.2 | |
Branched | Number of molecules | 2 |
Total formula weight | 1141.1 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 634.5 | |
All* | Total formula weight | 115300.8 |