7PEE

Crystal structure of extracellular part of human Trop2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Tumor-associated calcium signal transducer 2	polymer	250	28381.3	4	UniProt (P09758) Pfam (PF18635) Pfam (PF00086) Pfam (PF21283)	Homo sapiens (Human)	Cell surface glycoprotein Trop-2,Membrane component chromosome 1 surface marker 1,Pancreatic carcinoma marker protein GA733-1,Trop2EX
2	E, F (E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	2	In PDB GlyTouCan (G21290RB)
3	G, H (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	I, J (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	K, L, M, N (A, B, C, D)	water	water		18.0	30	Chemie (HOH)

Sequence modifications

A, B, C, D: 31 - 274 (UniProt: P09758)

PDB	External Database	Details
Gln 120	Asn 120	engineered mutation
Gln 208	Asn 208	engineered mutation
His 275	-	expression tag
His 276	-	expression tag
His 277	-	expression tag
His 278	-	expression tag
His 279	-	expression tag
His 280	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	113525.2
Branched	Number of molecules	2
	Total formula weight	1141.1
Non-Polymers*	Number of molecules	4
	Total formula weight	634.5
All*	Total formula weight	115300.8

*Water molecules are not included.