7PCD
HER2 IN COMPLEX WITH A COVALENT INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Receptor tyrosine-protein kinase erbB-2 | polymer | 327 | 36968.6 | 1 | UniProt (P04626) Pfam (PF07714) In PDB | Homo sapiens (Human) | Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2 |
| 2 | A | 1-[4-[4-[[3,5-bis(chloranyl)-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]pyrimido[5,4-d]pyrimidin-6-yl]piperazin-1-yl]-4-(3-fluoranylazetidin-1-yl)butan-1-one | non-polymer | 652.5 | 1 | Chemie (70I) | |||
| 3 | water | water | 18.0 | 108 | Chemie (HOH) |
Sequence modifications
A: 703 - 1029 (UniProt: P04626)
| PDB | External Database | Details |
|---|---|---|
| Ala 706 | Met 706 | conflict |
| Leu 711 | Gln 711 | conflict |
| Leu 712 | Met 712 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36968.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 652.5 | |
| All* | Total formula weight | 37621.1 |
