7PAD

The crystal structure of DW-0254 in complex with PDE6D

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	polymer	166	19353.0	1	UniProt (O43924) Pfam (PF05351)	Homo sapiens (Human)	GMP-PDE delta,Protein p17
2	B (B)	NICKEL (II) ION	non-polymer		58.7	1	Chemie (NI)
3	C (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	D (B)	~{N}-[(4-ethylphenyl)methyl]-3-[5-[2-(1~{H}-indol-3-yl)ethyl]-1,3,4-oxadiazol-2-yl]-~{N}-methyl-propanamide	non-polymer		416.5	1	Chemie (O7W)
5	E (B)	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	1	Chemie (EPE)
6	F (B)	water	water		18.0	142	Chemie (HOH)

Sequence modifications

B: 2 - 150 (UniProt: O43924)

PDB	External Database	Details
Met -15	-	initiating methionine
Gly -14	-	expression tag
Ser -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Gly -6	-	expression tag
Ser -5	-	expression tag
Glu -4	-	expression tag
Asn -3	-	expression tag
Leu -2	-	expression tag
Tyr -1	-	expression tag
Phe 0	-	expression tag
Gln 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	19353.0
Non-Polymers*	Number of molecules	4
	Total formula weight	805.6
All*	Total formula weight	20158.6

*Water molecules are not included.