7P72

The PDZ domain of SNX27 complexed with the PDZ-binding motif of MERS-E

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Sorting nexin-27,Annexin A2	polymer	426	47821.3	1	UniProt (Q96L92) UniProt (P07355) Pfam (PF00595) Pfam (PF00191)	Homo sapiens (Human)	Annexin II,Annexin-2,Calpactin I heavy chain,Calpactin-1 heavy chain,Chromobindin-8,Lipocortin II,Placental anticoagulant protein IV,PAP-IV,Protein I,p36
2	B (B)	Envelope small membrane protein	polymer	14	1596.7	1	UniProt (K9N5R3)	Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012)	E protein,sM protein
3	C, D, E, F, G (A)	CALCIUM ION	non-polymer		40.1	5	Chemie (CA)
4	H, I (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	J, K (A, B)	water	water		18.0	254	Chemie (HOH)

Sequence modifications

A: 39 - 141 (UniProt: Q96L92)

PDB	External Database	Details
Gly 35	-	expression tag
Ser 36	-	expression tag
His 37	-	expression tag
Met 38	-	expression tag
Gly 142	-	linker

A: 143 - 460 (UniProt: P07355)

PDB	External Database	Details
Glu 187	Ala 66	conflict

B: 73 - 82 (UniProt: K9N5R3)

PDB	External Database	Details
Thr 69	-	linker
Asp 70	-	linker
Asp 71	-	linker
Ser 72	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	49418.0
Non-Polymers*	Number of molecules	7
	Total formula weight	384.6
All*	Total formula weight	49802.6

*Water molecules are not included.