7P71

The PDZ domain of MAGI1_2 complexed with the PDZ-binding motif of HPV35-E6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1,Annexin A2	polymer	427	48099.8	2	UniProt (Q96QZ7) UniProt (P07355) Pfam (PF00595) Pfam (PF00191)	Homo sapiens (Human)	Atrophin-1-interacting protein 3,AIP-3,BAI1-associated protein 1,BAP-1,Membrane-associated guanylate kinase inverted 1,MAGI-1,Trinucleotide repeat-containing gene 19 protein,WW domain-containing protein 3,WWP3,Annexin II,Annexin-2,Calpactin I heavy chain,Calpactin-1 heavy chain,Chromobindin-8,Lipocortin II,Placental anticoagulant protein IV,PAP-IV,Protein I,p36
2	C, D (C, D)	Protein E6	polymer	13	1536.6	2	UniProt (P27228)	Human papillomavirus 35
3	E, F, G, L, M... (A, B)	CALCIUM ION	non-polymer		40.1	8	Chemie (CA)
4	H, I, J, P, Q (A, B)	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
5	K (A)	CITRIC ACID	non-polymer		192.1	1	Chemie (CIT)
6	S, T (A, B)	water	water		18.0	15	Chemie (HOH)

Sequence modifications

A, B: 455 - 558 (UniProt: Q96QZ7)

PDB	External Database	Details
Gly 452	-	expression tag
Ser 453	-	expression tag
Met 454	-	expression tag
Gly 559	-	linker
Ser 560	-	linker

A, B: 561 - 878 (UniProt: P07355)

PDB	External Database	Details
Glu 605	Ala 66	conflict

C, D: 141 - 149 (UniProt: P27228)

PDB	External Database	Details
Thr 137	-	linker
Asp 138	-	linker
Asp 139	-	linker
Ser 140	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	99272.9
Non-Polymers*	Number of molecules	14
	Total formula weight	973.2
All*	Total formula weight	100246.1

*Water molecules are not included.