7P3I
Crystal structure of human CD40/TNFRSF5 in complex with the anti-CD40 DARPin protein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Tumor necrosis factor receptor superfamily member 5 | polymer | 177 | 19654.0 | 2 | UniProt (P25942) Pfam (PF00020) | Homo sapiens (Human) | B-cell surface antigen CD40,Bp50,CD40L receptor,CDw40 |
| 2 | B, D (B, D) | Darpin | polymer | 159 | 16743.0 | 2 | synthetic construct | ||
| 3 | E, F (A, C) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 208 | Chemie (HOH) |
Sequence modifications
A, C: 21 - 193 (UniProt: P25942)
| PDB | External Database | Details |
|---|---|---|
| Leu 194 | - | expression tag |
| Val 195 | - | expression tag |
| Pro 196 | - | expression tag |
| Arg 197 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 72794.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 46.0 | |
| All* | Total formula weight | 72840.1 |
