7P2R
Crystal structure of mouse PRMT6 in complex with inhibitor EML980
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protein arginine N-methyltransferase 6 | polymer | 348 | 38954.3 | 2 | UniProt (Q6NZB1) Pfam (PF13649) Pfam (PF22528) | Mus musculus (house mouse) | Histone-arginine N-methyltransferase PRMT6 |
| 2 | C, E (A, B) | methyl 6-[4-[[N-[2-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate | non-polymer | 636.7 | 2 | Chemie (4R7) | |||
| 3 | D (B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 38 | Chemie (HOH) |
Sequence modifications
A, B: 34 - 378 (UniProt: Q6NZB1)
| PDB | External Database | Details |
|---|---|---|
| Gly 31 | - | expression tag |
| His 32 | - | expression tag |
| Met 33 | - | expression tag |
| Ser 53 | Cys 53 | engineered mutation |
| Leu 315 | Phe 315 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77908.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1657.7 | |
| All* | Total formula weight | 79566.3 |
