Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7P2R

Crystal structure of mouse PRMT6 in complex with inhibitor EML980

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0003682molecular_functionchromatin binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0006281biological_processDNA repair
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0008168molecular_functionmethyltransferase activity
A0008469molecular_functionhistone arginine N-methyltransferase activity
A0010821biological_processregulation of mitochondrion organization
A0016274molecular_functionprotein-arginine N-methyltransferase activity
A0018216biological_processpeptidyl-arginine methylation
A0032259biological_processmethylation
A0035241molecular_functionprotein-arginine omega-N monomethyltransferase activity
A0035242molecular_functionprotein-arginine omega-N asymmetric methyltransferase activity
A0035642molecular_functionhistone H3R17 methyltransferase activity
A0036211biological_processprotein modification process
A0042054molecular_functionhistone methyltransferase activity
A0042393molecular_functionhistone binding
A0044020molecular_functionhistone H4R3 methyltransferase activity
A0045892biological_processnegative regulation of DNA-templated transcription
A0062122molecular_functionhistone H3K37 methyltransferase activity
A0070611molecular_functionhistone H3R2 methyltransferase activity
A0070612molecular_functionhistone H2AR3 methyltransferase activity
A0090398biological_processcellular senescence
A0140592molecular_functionhistone H3R8 methyltransferase activity
A0140759molecular_functionhistone H3K56 methyltransferase activity
A0140903molecular_functionhistone H3R26 methyltransferase activity
A0140984molecular_functionhistone H4K12 methyltransferase activity
A1901796biological_processregulation of signal transduction by p53 class mediator
A1990259molecular_functionhistone H2AQ104 methyltransferase activity
A2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0003682molecular_functionchromatin binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0006281biological_processDNA repair
B0006325biological_processchromatin organization
B0006338biological_processchromatin remodeling
B0008168molecular_functionmethyltransferase activity
B0008469molecular_functionhistone arginine N-methyltransferase activity
B0010821biological_processregulation of mitochondrion organization
B0016274molecular_functionprotein-arginine N-methyltransferase activity
B0018216biological_processpeptidyl-arginine methylation
B0032259biological_processmethylation
B0035241molecular_functionprotein-arginine omega-N monomethyltransferase activity
B0035242molecular_functionprotein-arginine omega-N asymmetric methyltransferase activity
B0035642molecular_functionhistone H3R17 methyltransferase activity
B0036211biological_processprotein modification process
B0042054molecular_functionhistone methyltransferase activity
B0042393molecular_functionhistone binding
B0044020molecular_functionhistone H4R3 methyltransferase activity
B0045892biological_processnegative regulation of DNA-templated transcription
B0062122molecular_functionhistone H3K37 methyltransferase activity
B0070611molecular_functionhistone H3R2 methyltransferase activity
B0070612molecular_functionhistone H2AR3 methyltransferase activity
B0090398biological_processcellular senescence
B0140592molecular_functionhistone H3R8 methyltransferase activity
B0140759molecular_functionhistone H3K56 methyltransferase activity
B0140903molecular_functionhistone H3R26 methyltransferase activity
B0140984molecular_functionhistone H4K12 methyltransferase activity
B1901796biological_processregulation of signal transduction by p53 class mediator
B1990259molecular_functionhistone H2AQ104 methyltransferase activity
B2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
AGLU158
AGLU167
BGLU158
BGLU167

site_idSWS_FT_FI2
Number of Residues10
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AHIS60
BGLU144
AARG69
AGLY93
AGLU115
AGLU144
BHIS60
BARG69
BGLY93
BGLU115

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Asymmetric dimethylarginine; by autocatalysis => ECO:0000250
ChainResidueDetails
AARG38
BARG38

227344

PDB entries from 2024-11-13

PDB statisticsPDBj update infoContact PDBjnumon