7P2B

Crystal structure of human gelsolin amyloid mutant A551P

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Gelsolin	polymer	778	85543.7	2	UniProt (P06396) Pfam (PF00626) In PDB	Homo sapiens (Human)	AGEL,Actin-depolymerizing factor,ADF,Brevin
2	A, B	SULFATE ION	non-polymer		96.1	7	Chemie (SO4)
3	A, B	GLYCEROL	non-polymer		92.1	8	Chemie (GOL)
4	B	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5		water	water		18.0	103	Chemie (HOH)

Sequence modifications

A, B: 1 - 755 (UniProt: P06396)

PDB	External Database	Details
Met -22	-	initiating methionine
Gly -21	-	expression tag
Ser -20	-	expression tag
Ser -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
Ser -12	-	expression tag
Ser -11	-	expression tag
Gly -10	-	expression tag
Leu -9	-	expression tag
Val -8	-	expression tag
Pro -7	-	expression tag
Arg -6	-	expression tag
Gly -5	-	expression tag
Ser -4	-	expression tag
His -3	-	expression tag
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag
Pro 551	Ala 578	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	171087.5
Non-Polymers*	Number of molecules	16
	Total formula weight	1444.6
All*	Total formula weight	172532.1

*Water molecules are not included.