7P1A
Carbonic Anhydrase VII Sultam Based Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Carbonic anhydrase 7 | polymer | 274 | 30925.7 | 1 | UniProt (P43166) Pfam (PF00194) | Homo sapiens (Human) | Carbonate dehydratase VII,Carbonic anhydrase VII,CA-VII |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D (A) | 4-[2-[4-[(4-methylphenyl)methyl]-1,1-bis(oxidanylidene)-1,2,4-thiadiazinan-2-yl]ethyl]benzenesulfonamide | non-polymer | 423.6 | 1 | Chemie (4IQ) | |||
| 5 | E (A) | water | water | 18.0 | 179 | Chemie (HOH) |
Sequence modifications
A: -1 - 262 (UniProt: P43166)
| PDB | External Database | Details |
|---|---|---|
| Met -3 | - | initiating methionine |
| Gly -2 | - | expression tag |
| Ser 183 | Cys 185 | engineered mutation |
| Ser 217 | Cys 219 | engineered mutation |
| Leu 263 | - | expression tag |
| Glu 264 | - | expression tag |
| His 265 | - | expression tag |
| His 266 | - | expression tag |
| His 267 | - | expression tag |
| His 268 | - | expression tag |
| His 269 | - | expression tag |
| His 270 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30925.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 581.1 | |
| All* | Total formula weight | 31506.7 |
