7P0E
Crystal structure of human filamin C domains 14-15 cardiovascular disease causing mutation G1676R
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Isoform 2 of Filamin-C | polymer | 205 | 21581.2 | 2 | UniProt (Q14315) Pfam (PF00630) | Homo sapiens (Human) | FLN-C,FLNc,ABP-280-like protein,ABP-L,Actin-binding-like protein,Filamin-2,Gamma-filamin |
| 2 | C, E, F, G (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 3 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 320 | Chemie (HOH) |
Sequence modifications
A, B: 1534 - 1736 (UniProt: Q14315)
| PDB | External Database | Details |
|---|---|---|
| Gly 1532 | - | expression tag |
| Pro 1533 | - | expression tag |
| Arg 1676 | Gly 1676 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43162.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 430.4 | |
| All* | Total formula weight | 43592.8 |
