7OZ5
Crystal structure of HIV-1 reverse transcriptase with a double stranded DNA in complex with fragment 166 at the transient P-pocket.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, C) | Reverse transcriptase/ribonuclease H | polymer | 556 | 64038.4 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) | Exoribonuclease H,p66 RT |
| 2 | B, F (B, D) | Gag-Pol polyprotein | polymer | 444 | 51928.6 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus type 1 BH10 | Pr160Gag-Pol |
| 3 | C, G (T, E) | DNA (28-MER) | polymer | 28 | 8680.6 | 2 | Human immunodeficiency virus type 1 BH10 | ||
| 4 | D, H (P, F) | DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*G)-3') | polymer | 21 | 6416.1 | 2 | Homo sapiens | ||
| 5 | I, J (I, J) | beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | branched | 342.3 | 2 | In PDB BIRD (PRD_900003) | |||
| 6 | AA, CA, K, L, M... (E, F, A, B, T...) | CADMIUM ION | non-polymer | 112.4 | 18 | Chemie (CD) | |||
| 7 | BA (F) | (1~{R},2~{R})-2-phenyl-~{N}-(1,3-thiazol-2-yl)cyclopropane-1-carboxamide | non-polymer | 244.3 | 1 | Chemie (3IR) | |||
| 8 | DA, EA, FA (T, D, E) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 554 (UniProt: P03366)
B, D: 1 - 428 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Val 0 | - | expression tag |
| Cys 63 | Ile 662 | conflict |
| Ser 280 | Cys 879 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -15 | - | initiating methionine |
| Ala -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| Ala -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Glu -5 | - | expression tag |
| Val -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 280 | Cys 879 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 262127.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 684.6 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 2267.7 | |
| All* | Total formula weight | 265079.7 |
