7OZ2
Crystal structure of HIV-1 reverse transcriptase with a double stranded DNA showing a transient P-pocket
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Reverse transcriptase/ribonuclease H | polymer | 556 | 64038.4 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) | Exoribonuclease H,p66 RT |
2 | B, D | Gag-Pol polyprotein | polymer | 444 | 51928.6 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | Human immunodeficiency virus type 1 BH10 | Pr160Gag-Pol |
3 | T, E | DNA (28-MER) | polymer | 28 | 8680.6 | 2 | Human immunodeficiency virus type 1 BH10 | ||
4 | P, F | DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*G)-3') | polymer | 21 | 6416.1 | 2 | Homo sapiens | ||
5 | C, D, E, A, F... | CADMIUM ION | non-polymer | 112.4 | 27 | Chemie (CD) | |||
6 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
7 | C | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
8 | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 554 (UniProt: P03366)
B, D: 1 - 428 (UniProt: P03366)
PDB | External Database | Details |
---|---|---|
Met -1 | - | initiating methionine |
Val 0 | - | expression tag |
Cys 63 | Ile 662 | conflict |
Ser 280 | Cys 879 | conflict |
PDB | External Database | Details |
---|---|---|
Met -15 | - | initiating methionine |
Ala -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
Ala -7 | - | expression tag |
Leu -6 | - | expression tag |
Glu -5 | - | expression tag |
Val -4 | - | expression tag |
Leu -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
Ser 280 | Cys 879 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 262127.4 | |
Non-Polymers* | Number of molecules | 30 |
Total formula weight | 3251.5 | |
All* | Total formula weight | 265378.9 |