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7OW7

EIF6-bound large subunit of the human ribosome

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
28S rRNApolymer50701641134.81Homo sapiens
2B
(B)
5S rRNApolymer12138998.11GenBank (23898)Homo sapiens (Human)
3C
(C)
5.8S ribosomal RNApolymer15750462.91Homo sapiens
4D
(D)
60S ribosomal protein L8polymer25728088.91UniProt (P62917)
Pfam (PF00181)
Pfam (PF03947)
Homo sapiens (Human)Large ribosomal subunit protein uL2
5E
(E)
60S ribosomal protein L3 isoform apolymer43048923.21Homo sapiens
6F
(F)
60S ribosomal protein L4polymer42747804.61UniProt (P36578)
Pfam (PF00573)
Pfam (PF14374)
Homo sapiens (Human)60S ribosomal protein L1,Large ribosomal subunit protein uL4
7G
(G)
60S ribosomal protein L5polymer29734426.81UniProt (P46777)
Pfam (PF17144)
Pfam (PF14204)
Homo sapiens (Human)Large ribosomal subunit protein uL18
8H
(H)
60S ribosomal protein L6polymer28832895.21UniProt (Q02878)
Pfam (PF03868)
Pfam (PF01159)
Homo sapiens (Human)Large ribosomal subunit protein eL6,Neoplasm-related protein C140,Tax-responsive enhancer element-binding protein 107,TaxREB107
9I
(m)
60S ribosomal protein L7polymer24829291.01UniProt (P18124)
Pfam (PF08079)
Pfam (PF00327)
Homo sapiens (Human)Large ribosomal subunit protein uL30
10J
(n)
60S ribosomal protein L7apolymer26630061.81UniProt (P62424)
Pfam (PF01248)
Homo sapiens (Human)Large ribosomal subunit protein eL8,PLA-X polypeptide,Surfeit locus protein 3
11K
(o)
60S ribosomal protein L9polymer19021655.31UniProt (P32969)
Pfam (PF00347)
Homo sapiens (Human)Large ribosomal subunit protein uL6
12L
(p)
60S ribosomal protein L10-likepolymer21424617.01UniProt (Q96L21)
Pfam (PF00252)
Homo sapiens (Human)Large ribosomal subunit protein uL16-like
13M
(q)
60S ribosomal protein L11polymer17820288.51UniProt (P62913)
Pfam (PF00281)
Pfam (PF00673)
Homo sapiens (Human)CLL-associated antigen KW-12,Large ribosomal subunit protein uL5
14N
(r)
60S ribosomal protein L13polymer21124321.71UniProt (P26373)
Pfam (PF01294)
Homo sapiens (Human)Breast basic conserved protein 1,Large ribosomal subunit protein eL13
15O
(s)
60S ribosomal protein L14polymer22023840.41UniProt (Q6IPH7)
Pfam (PF01929)
Homo sapiens (Human)
16P
(t)
60S ribosomal protein L15polymer20424207.31UniProt (P61313)
Pfam (PF00827)
Homo sapiens (Human)Large ribosomal subunit protein eL15
17Q
(I)
60S ribosomal protein L13apolymer20323633.41UniProt (P40429)
Pfam (PF00572)
Homo sapiens (Human)23 kDa highly basic protein,Large ribosomal subunit protein uL13
18R
(J)
60S ribosomal protein L17polymer18421443.21UniProt (P18621)
Pfam (PF00237)
Homo sapiens (Human)60S ribosomal protein L23,Large ribosomal subunit protein uL22,PD-1
19S
(K)
60S ribosomal protein L18polymer18821687.71UniProt (Q07020)
Pfam (PF17135)
Homo sapiens (Human)Large ribosomal subunit protein eL18
20T
(L)
60S ribosomal protein L19polymer19623535.31UniProt (P84098)
Pfam (PF01280)
Homo sapiens (Human)Large ribosomal subunit protein eL19
21U
(M)
60S ribosomal protein L18apolymer17620808.51UniProt (Q02543)
Pfam (PF01775)
Homo sapiens (Human)Large ribosomal subunit protein eL20
22V
(N)
60S ribosomal protein L21polymer16018610.01UniProt (P46778)
Pfam (PF01157)
Homo sapiens (Human)Large ribosomal subunit protein eL21
23W
(R)
60S ribosomal protein L23apolymer15617740.21UniProt (P62750)
Pfam (PF03939)
Pfam (PF00276)
Homo sapiens (Human)Large ribosomal subunit protein uL23
24X
(S)
60S ribosomal protein L26polymer14517303.41UniProt (P61254)
Pfam (PF16906)
Pfam (PF00467)
Homo sapiens (Human)Large ribosomal subunit protein uL24
25Y
(T)
60S ribosomal protein L27polymer13615835.81UniProt (P61353)
Pfam (PF00467)
Pfam (PF01777)
Homo sapiens (Human)Large ribosomal subunit protein eL27
26Z
(U)
60S ribosomal protein L27apolymer14816604.51UniProt (P46776)
Pfam (PF00828)
Homo sapiens (Human)Large ribosomal subunit protein uL15
27AA
(V)
60S ribosomal protein L29polymer15917804.31UniProt (P47914)
Pfam (PF01779)
Homo sapiens (Human)Cell surface heparin-binding protein HIP,Large ribosomal subunit protein eL29
28BA
(W)
60S ribosomal protein L30polymer11512805.11UniProt (P62888)
Pfam (PF01248)
Homo sapiens (Human)Large ribosomal subunit protein eL30
29CA
(X)
60S ribosomal protein L31polymer12514494.91UniProt (P62899)
Pfam (PF01198)
Homo sapiens (Human)Large ribosomal subunit protein eL31
30DA
(Y)
60S ribosomal protein L32polymer13515898.91UniProt (P62910)
Pfam (PF01655)
Homo sapiens (Human)Large ribosomal subunit protein eL32
31EA
(Z)
60S ribosomal protein L35apolymer11012564.71UniProt (P18077)
Pfam (PF01247)
Homo sapiens (Human)Cell growth-inhibiting gene 33 protein,Large ribosomal subunit protein eL33
32FA
(a)
60S ribosomal protein L34polymer11713326.11UniProt (P49207)
Pfam (PF01199)
Homo sapiens (Human)Large ribosomal subunit protein eL34
33GA
(b)
60S ribosomal protein L35polymer12314593.61UniProt (P42766)
Pfam (PF00831)
Homo sapiens (Human)Large ribosomal subunit protein uL29
34HA
(c)
60S ribosomal protein L36polymer10512290.91UniProt (Q9Y3U8)
Pfam (PF01158)
Homo sapiens (Human)Large ribosomal subunit protein eL36
35IA
(d)
60S ribosomal protein L37polymer9711111.01UniProt (P61927)
Pfam (PF01907)
Homo sapiens (Human)G1.16,Large ribosomal subunit protein eL37
36JA
(e)
60S ribosomal protein L38polymer708192.91UniProt (P63173)
Pfam (PF01781)
Homo sapiens (Human)Large ribosomal subunit protein eL38
37KA
(f)
60S ribosomal protein L39polymer15718023.21Homo sapiens
38LA
(i)
60S ribosomal protein L36apolymer10612477.01UniProt (P83881)
Pfam (PF00935)
Homo sapiens (Human)60S ribosomal protein L44,Cell growth-inhibiting gene 15 protein,Cell migration-inducing gene 6 protein,Large ribosomal subunit protein eL42
39MA
(j)
60S ribosomal protein L37apolymer9210299.41UniProt (P61513)
Pfam (PF01780)
Homo sapiens (Human)Large ribosomal subunit protein eL43
40NA
(k)
60S ribosomal protein L28polymer13715784.61UniProt (P46779)
Pfam (PF01778)
Homo sapiens (Human)Large ribosomal subunit protein eL28
41OA
(P)
Eukaryotic translation initiation factor 6polymer24526620.01UniProt (P56537)
Pfam (PF01912)
Homo sapiens (Human)eIF-6,B(2)GCN homolog,B4 integrin interactor,CAB,p27(BBP)
42PA
(Q)
60S ribosomal protein L23polymer14014892.51UniProt (P62829)
Pfam (PF00238)
Homo sapiens (Human)60S ribosomal protein L17,Large ribosomal subunit protein uL14
43QA
(u)
60S ribosomal protein L24polymer15717825.11UniProt (P83731)
Pfam (PF01246)
Homo sapiens (Human)60S ribosomal protein L30,Large ribosomal subunit protein eL24
44AB, AC, AD, AE, AF...
(A, L, B, C, Q...)
MAGNESIUM IONnon-polymer24.3223Chemie (MG)
45FP, GP, IP, KP, SA
(a, d, i, j, A)
ZINC IONnon-polymer65.45Chemie (ZN)
46AJ, AK, AL, AM, AN...
(A, N, V, Y, Z...)
POTASSIUM IONnon-polymer39.1153Chemie (K)
47CO, DO, EO, WO
(A, t)
SODIUM IONnon-polymer23.04Chemie (NA)
48SO
(G)
BROMIDE IONnon-polymer79.91Chemie (BR)
49AQ, AR, BQ, BR, CQ...
(r, k, s, P, t...)
waterwater18.09044Chemie (HOH)
Sequence modifications
H: 1 - 288 (UniProt: Q02878)
PDBExternal DatabaseDetails
Arg 40Gly 40conflict
Asn 41Lys 41conflict
p: 1 - 214 (UniProt: Q96L21)
PDBExternal DatabaseDetails
Cys 49Gly 49conflict
e: 1 - 70 (UniProt: P63173)
PDBExternal DatabaseDetails
Pro 16Arg 16conflict
Ile 23Val 23conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains43
Total formula weight2567223.6
Non-Polymers*Number of molecules386
Total formula weight11900.9
All*Total formula weight2579124.5
*Water molecules are not included.

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PDB entries from 2024-11-13

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