7OW6
Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS G12D peptide (VVVGADGVGK)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MHC class I antigen | polymer | 276 | 31952.2 | 1 | UniProt (A0A583ZB34) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (human) | |
| 2 | B (B) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | C (C) | KRAS G12D peptide (VVVGADGVGK) | polymer | 10 | 901.0 | 1 | UniProt (P01111) | Homo sapiens | Transforming protein N-Ras,GTPase NRas |
| 4 | D (D) | TCR alpha | polymer | 203 | 22891.2 | 1 | Homo sapiens (Human) | ||
| 5 | E (E) | TCR beta | polymer | 246 | 27602.9 | 1 | Homo sapiens (Human) | ||
| 6 | F, G (E) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 7 | H, I, J, K (A, B, D, E) | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A: 1 - 275 (UniProt: A0A583ZB34)
B: 1 - 99 (UniProt: P61769)
C: 1 - 10 (UniProt: P01111)
| PDB | External Database | Details |
|---|---|---|
| Pro 276 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Asp 6 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 95226.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 192.1 | |
| All* | Total formula weight | 95418.8 |
