7OW4

Crystal structure of HLA-A*11:01 in complex with KRAS G12D peptide (VVVGADGVGK)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (A, D, G, J)	MHC class I antigen	polymer	276	31952.2	4	UniProt (A0A583ZB34) Pfam (PF00129) Pfam (PF07654)	Homo sapiens (Human)
2	B, E, H, K (B, E, H, K)	Beta-2-microglobulin	polymer	100	11879.4	4	UniProt (P61769) Pfam (PF07654)	Homo sapiens (Human)
3	C, F, I, L (C, F, I, L)	KRAS G12D peptide (VVVGADGVGK)	polymer	10	901.0	4	UniProt (P01111)	Homo sapiens	Transforming protein N-Ras,GTPase NRas
4	M, N, O, P, Q (D, G, H, J, K)	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
5	AA, BA, CA, R, S... (J, K, L, A, B...)	water	water		18.0	1009	Chemie (HOH)

Sequence modifications

A, D, G, J: 1 - 275 (UniProt: A0A583ZB34)

PDB	External Database	Details
Pro 276	-	expression tag

B, E, H, K: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	initiating methionine

C, F, I, L: 1 - 10 (UniProt: P01111)

PDB	External Database	Details
Asp 6	Gly 12	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	178930.2
Non-Polymers*	Number of molecules	5
	Total formula weight	480.3
All*	Total formula weight	179410.6

*Water molecules are not included.