7OW4
Crystal structure of HLA-A*11:01 in complex with KRAS G12D peptide (VVVGADGVGK)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D, G, J | MHC class I antigen | polymer | 276 | 31952.2 | 4 | UniProt (A0A583ZB34) Pfam (PF00129) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
2 | B, E, H, K | Beta-2-microglobulin | polymer | 100 | 11879.4 | 4 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
3 | C, F, I, L | KRAS G12D peptide (VVVGADGVGK) | polymer | 10 | 901.0 | 4 | UniProt (P01111) In PDB | Homo sapiens | Transforming protein N-Ras,GTPase NRas |
4 | D, G, H, J, K | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
5 | water | water | 18.0 | 1009 | Chemie (HOH) |
Sequence modifications
A, D, G, J: 1 - 275 (UniProt: A0A583ZB34)
B, E, H, K: 1 - 99 (UniProt: P61769)
C, F, I, L: 1 - 10 (UniProt: P01111)
PDB | External Database | Details |
---|---|---|
Pro 276 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
PDB | External Database | Details |
---|---|---|
Asp 6 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 178930.2 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 480.3 | |
All* | Total formula weight | 179410.6 |