7OUG

STLV-1 intasome:B56 in complex with the strand-transfer inhibitor raltegravir

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, F, G (D, E, A, B)	Integrase	polymer	301	33943.5	4	UniProt (Q4QY51) Pfam (PF02022) Pfam (PF00665) Pfam (PF00552)	Simian T-lymphotropic virus 1
2	C, H (F, C)	Isoform 3 of PC4 and SFRS1-interacting protein,Isoform Gamma-2 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	polymer	697	80394.7	2	UniProt (O75475) UniProt (Q13362) Pfam (PF00855) Pfam (PF01603)	Homo sapiens (Human)	PP2A B subunit isoform B'-gamma,PP2A B subunit isoform B56-gamma,PP2A B subunit isoform PR61-gamma,PP2A B subunit isoform R5-gamma,Renal carcinoma antigen NY-REN-29
3	D, I (I, K)	DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3')	polymer	30	9221.9	2		Simian T-lymphotropic virus 1
4	E, J (J, L)	DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3')	polymer	28	8593.6	2		Simian T-lymphotropic virus 1
5	K, L, P, Q (D, E, A, B)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
6	M, N, R, S (E, B)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
7	O, T (E, B)	N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(1-methyl-1-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}ethyl)-6-oxo-1,6-di hydropyrimidine-4-carboxamide	non-polymer		444.4	2	Chemie (RLT)
8	U, V (E, B)	water	water		18.0	8	Chemie (HOH)

Sequence modifications

D, E, A, B: -2 - 297 (UniProt: Q4QY51)

PDB	External Database	Details
Gly -3	-	expression tag
Glu -1	Val 598	expression tag
Phe 0	Leu 599	expression tag
Glu 219	Ala 818	engineered mutation

F, C: -315 - 9 (UniProt: O75475)

PDB	External Database	Details
Ser -316	-	expression tag
Phe 10	-	linker

F, C: 11 - 380 (UniProt: Q13362)

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	332194.5
Non-Polymers*	Number of molecules	10
	Total formula weight	1247.7
All*	Total formula weight	333442.1

*Water molecules are not included.