7OPR

Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CB1 in C123

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Synaptotagmin-like protein 2,Ras-related protein Rab-27A	polymer	229	25857.2	2	UniProt (Q9HCH5) UniProt (P51159) Pfam (PF02318) Pfam (PF00071) In PDB	Homo sapiens (Human)	Breast cancer-associated antigen SGA-72M,Exophilin-4,Rab-27,GTP-binding protein Ram
2	A, B	PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER	non-polymer		522.2	2	Chemie (GNP)
3	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	A, B	GLYCEROL	non-polymer		92.1	9	Chemie (GOL)
5	A, B	~{N}-[1-(2-pyridin-2-ylethyl)benzimidazol-2-yl]propanamide	non-polymer		294.4	2	Chemie (05Y)	Homo sapiens
6		water	water		18.0	248	Chemie (HOH)

Sequence modifications

A, B: -35 - -8 (UniProt: Q9HCH5)

PDB	External Database	Details
His -37	-	expression tag
Met -36	-	expression tag
Gly -7	-	linker
Ser -6	-	linker
Gly -4	-	linker
Ser -3	-	linker
Gly -2	-	linker
Ser -1	-	linker
Gly 0	-	linker

A, B: 1 - 192 (UniProt: P51159)

PDB	External Database	Details
Leu 78	Gln 78	engineered mutation
Ser 188	Cys 188	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	51714.3
Non-Polymers*	Number of molecules	15
	Total formula weight	2510.6
All*	Total formula weight	54224.9

*Water molecules are not included.