7OOX
Crystal structure of PIM1 in complex with ARC-3126
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase pim-1 | polymer | 313 | 35590.5 | 1 | UniProt (P11309) Pfam (PF00069) | Homo sapiens (Human) | |
| 2 | B (B) | Inhibitor ARC-3126 | polymer | 9 | 1494.6 | 1 | BIRD (PRD_002346) | synthetic construct | |
| 3 | C (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | D, E, F (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 258 | Chemie (HOH) |
Sequence modifications
A: 1 - 312 (UniProt: P11309)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Gly 250 | Arg 250 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 37085.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 281.2 | |
| All* | Total formula weight | 37366.3 |
