7OHO

Crystal structure of AP2 FCHO2 chimera

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	AAA	AP-2 complex subunit alpha-2	polymer	621	69656.3	1	UniProt (P18484) Pfam (PF01602) In PDB	Rattus norvegicus (Rat)	100 kDa coated vesicle protein C,Adaptor protein complex AP-2 subunit alpha-2,Adaptor-related protein complex 2 subunit alpha-2,Alpha-adaptin C,Alpha2-adaptin,Clathrin assembly protein complex 2 alpha-C large chain,Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit
2	BBB	AP-2 complex subunit beta,F-BAR domain only protein 2	polymer	636	71857.5	1	UniProt (P63010) UniProt (Q0JRZ9) Pfam (PF01602) In PDB	Homo sapiens (Human)	AP105B,Adaptor protein complex AP-2 subunit beta,Adaptor-related protein complex 2 subunit beta,Beta-2-adaptin,Beta-adaptin,Clathrin assembly protein complex 2 beta large chain,Plasma membrane adaptor HA2/AP2 adaptin beta subunit
3	MMM	AP-2 complex subunit mu	polymer	446	51044.1	1	UniProt (P84092) Pfam (PF01217) Pfam (PF00928) In PDB	Rattus norvegicus (Rat)	AP-2 mu chain,Adaptor protein complex AP-2 subunit mu,Adaptor-related protein complex 2 subunit mu,Clathrin assembly protein complex 2 mu medium chain,Clathrin coat assembly protein AP50,Clathrin coat-associated protein AP50,Mu2-adaptin,Plasma membrane adaptor AP-2 50 kDa protein
4	SSS	AP-2 complex subunit sigma	polymer	142	17038.7	1	UniProt (P62743) Pfam (PF01217) In PDB	Mus musculus (Mouse)	Adaptor protein complex AP-2 subunit sigma,Adaptor-related protein complex 2 subunit sigma,Clathrin assembly protein 2 sigma small chain,Clathrin coat assembly protein AP17,Clathrin coat-associated protein AP17,Plasma membrane adaptor AP-2 17 kDa protein,Sigma-adaptin 3b,Sigma2-adaptin
5	AAA	INOSITOL HEXAKISPHOSPHATE	non-polymer		660.0	1	Chemie (IHP)
6	AAA, MMM	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)

Sequence modifications

AAA: 1 - 621 (UniProt: P18484)

PDB	External Database	Details
Glu 272	-	insertion

BBB: 1 - 542 (UniProt: P63010)
BBB: 543 - 629 (UniProt: Q0JRZ9)

PDB	External Database	Details
Phe 626	Ser 441	conflict
Gly 630	-	expression tag
His 631	-	expression tag
His 632	-	expression tag
His 633	-	expression tag
His 634	-	expression tag
His 635	-	expression tag
His 636	-	expression tag

MMM: 1 - 435 (UniProt: P84092)

PDB	External Database	Details
Met 222	-	insertion
Glu 222	-	insertion
Gln 222	-	insertion
Lys 222	-	insertion
Leu 222	-	insertion
Ile 222	-	insertion
Ser 222	-	insertion
Glu 222	-	insertion
Glu 222	-	insertion
Asp 222	-	insertion
Leu 222	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	209596.6
Non-Polymers*	Number of molecules	5
	Total formula weight	1028.4
All*	Total formula weight	210625.0

*Water molecules are not included.