7OGS

X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an interferon-stimulated response element

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, E, F	Interferon regulatory factor 4	polymer	141	16306.5	4	UniProt (Q15306) Pfam (PF00605) In PDB	Homo sapiens (Human)	IRF-4,Lymphocyte-specific interferon regulatory factor,LSIRF,Multiple myeloma oncogene 1,NF-EM5
2	C, G	DNA (5'-D(P*TP*GP*TP*AP*CP*TP*TP*TP*CP*GP*GP*TP*TP*TP*CP*AP*GP*TP*TP*A)-3')	polymer	20	6121.0	2		synthetic construct
3	D, H	DNA (5'-D(P*AP*TP*AP*AP*CP*TP*GP*AP*AP*AP*CP*CP*GP*AP*AP*AP*GP*TP*AP*C)-3')	polymer	20	6144.0	2		synthetic construct

Sequence modifications

A, B, E, F: 20 - 139 (UniProt: Q15306)

PDB	External Database	Details
Met -1	-	initiating methionine
Gly 0	-	expression tag
Ser 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
Ser 8	-	expression tag
Ala 9	-	expression tag
Ala 10	-	expression tag
Leu 11	-	expression tag
Glu 12	-	expression tag
Val 13	-	expression tag
Leu 14	-	expression tag
Phe 15	-	expression tag
Gln 16	-	expression tag
Gly 17	-	expression tag
Pro 18	-	expression tag
Gly 19	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	89755.9
All*	Total formula weight	89755.9

*Water molecules are not included.