7OGI
Human Cyclophilin D in complex with N-(5-ethyl-4-oxo-1,2,3,4,5,6-hexahydro-1,5-benzodiazocin-8-yl)-7methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Peptidyl-prolyl cis-trans isomerase F, mitochondrial | polymer | 165 | 17783.3 | 1 | UniProt (P30405) Pfam (PF00160) | Homo sapiens (Human) | PPIase F,Cyclophilin D,CypD,Cyclophilin F,Mitochondrial cyclophilin,CyP-M,Rotamase F |
| 2 | B (A) | N-(5-ethyl-4-oxidanylidene-1,2,3,6-tetrahydro-1,5-benzodiazocin-8-yl)-7-methyl-2-oxidanylidene-1H-pyrazolo[1,5-a]pyrimidine-6-carboxamide | non-polymer | 394.4 | 1 | Chemie (VDH) | |||
| 3 | C (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 4 | D (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 5 | E (A) | water | water | 18.0 | 282 | Chemie (HOH) |
Sequence modifications
A: 2 - 165 (UniProt: P30405)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Ile 133 | Lys 175 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17783.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 666.8 | |
| All* | Total formula weight | 18450.1 |
