7OGI
Human Cyclophilin D in complex with N-(5-ethyl-4-oxo-1,2,3,4,5,6-hexahydro-1,5-benzodiazocin-8-yl)-7methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000413 | biological_process | protein peptidyl-prolyl isomerization |
| A | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| A | 0006457 | biological_process | protein folding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue VDH A 201 |
| Chain | Residue |
| A | HIS54 |
| A | ASN102 |
| A | THR107 |
| A | GLY109 |
| A | GLN111 |
| A | HOH306 |
| A | HOH331 |
| A | HOH393 |
| A | HOH424 |
| A | ARG55 |
| A | GLN63 |
| A | GLY72 |
| A | THR73 |
| A | GLY74 |
| A | SER81 |
| A | ARG82 |
| A | LYS91 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue DMS A 202 |
| Chain | Residue |
| A | ARG55 |
| A | PHE60 |
| A | MET61 |
| A | GLN63 |
| A | ALA101 |
| A | PHE113 |
| A | HOH393 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue PG4 A 203 |
| Chain | Residue |
| A | TYR79 |
| A | VAL93 |
| A | PRO95 |
| A | HIS131 |
| A | HOH334 |
| A | HOH413 |
Functional Information from PROSITE/UniProt
| site_id | PS00170 |
| Number of Residues | 18 |
| Details | CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgStFHRVIpsFMcQAG |
| Chain | Residue | Details |
| A | TYR48-GLY65 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | LYS25 | |
| Chain | Residue | Details |
| A | LYS44 | |
| A | ILE133 | |
| A | LYS148 | |
| Chain | Residue | Details |
| A | LYS125 | |
| Chain | Residue | Details |
| A | CYS161 | |
