7OFV
NMR-guided design of potent and selective EphA4 agonistic ligands
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ephrin type-A receptor 4 | polymer | 185 | 21259.1 | 1 | UniProt (P54764) Pfam (PF01404) | Homo sapiens (Human) | EPH-like kinase 8,EK8,hEK8,Tyrosine-protein kinase TYRO1,Tyrosine-protein kinase receptor SEK |
| 2 | B (B) | EphA4 agonist ligand | polymer | 6 | 957.2 | 1 | synthetic construct | ||
| 3 | C (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 302 | Chemie (HOH) |
Sequence modifications
A: 29 - 209 (UniProt: P54764)
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | - | expression tag |
| Ser 26 | - | expression tag |
| His 27 | - | expression tag |
| Met 28 | - | expression tag |
| Ala 204 | Cys 204 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 22216.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 59.0 | |
| All* | Total formula weight | 22275.3 |
