7O71
Cryo-EM structure of a respiratory complex I
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NADH-ubiquinone oxidoreductase 78 kDa subunit | polymer | 728 | 79088.1 | 1 | UniProt (Q9UUU3) Pfam (PF13510) Pfam (PF10588) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) Pfam (PF09326) UniProt (by SIFTS) (F2Z6F1) | Yarrowia lipolytica (Candida lipolytica) | NUAM protein |
| 2 | B (B) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 488 | 53829.5 | 1 | UniProt (Q9UUU2) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) UniProt (by SIFTS) (F2Z660) | Yarrowia lipolytica (Candida lipolytica) | |
| 3 | C (C) | NUCM protein | polymer | 466 | 52521.9 | 1 | UniProt (Q9UUU1) Pfam (PF00346) UniProt (by SIFTS) (F2Z626) | Yarrowia lipolytica | |
| 4 | D (G) | Subunit NUGM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 281 | 32389.6 | 1 | UniProt (Q9UUU0) Pfam (PF00329) UniProt (by SIFTS) (F2Z6D7) | Yarrowia lipolytica (Candida lipolytica) | |
| 5 | E (H) | Subunit NUHM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 243 | 27247.4 | 1 | UniProt (Q9UUT9) Pfam (PF01257) UniProt (by SIFTS) (F2Z6C0) | Yarrowia lipolytica (Candida lipolytica) | |
| 6 | F (I) | Subunit NUIM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 229 | 25682.3 | 1 | UniProt (Q9UUT8) Pfam (PF12838) UniProt (by SIFTS) (F2Z619) | Yarrowia lipolytica (Candida lipolytica) | |
| 7 | G (K) | Subunit NUKM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 210 | 23455.2 | 1 | UniProt (Q9UUT7) Pfam (PF01058) UniProt (by SIFTS) (Q6C2Q1) | Yarrowia lipolytica (Candida lipolytica) | |
| 8 | H (L) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 89 | 9843.9 | 1 | UniProt (S5U4U1) Pfam (PF00420) UniProt (by SIFTS) (Q9B6D4) | Yarrowia lipolytica | |
| 9 | I (S) | Subunit NESM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 249 | 28479.9 | 1 | UniProt (Q6ZY23) UniProt (by SIFTS) (F2Z673) | Yarrowia lipolytica | |
| 10 | J (j) | Subunit NB5M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 93 | 10494.9 | 1 | UniProt (Q6ZY24) UniProt (by SIFTS) (B5RSK9) | Yarrowia lipolytica (Candida lipolytica) | |
| 11 | K (1) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 341 | 38389.3 | 1 | UniProt (S5U3V2) Pfam (PF00146) UniProt (by SIFTS) (Q9B6E8) | Yarrowia lipolytica | |
| 12 | L (2) | NADH dehydrogenase subunit 2 | polymer | 469 | 53381.4 | 1 | UniProt (S5U4R9) Pfam (PF00361) UniProt (by SIFTS) (Q9B6C8) | Yarrowia lipolytica | |
| 13 | M (3) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 128 | 14506.3 | 1 | UniProt (S5TMS4) Pfam (PF00507) UniProt (by SIFTS) (Q9B6C7) | Yarrowia lipolytica | |
| 14 | N (4) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 486 | 54534.7 | 1 | UniProt (S5TMP9) Pfam (PF00361) UniProt (by SIFTS) (Q9B6D6) | Yarrowia lipolytica | |
| 15 | O (5) | NADH-ubiquinone oxidoreductase chain 5 | polymer | 655 | 73768.7 | 1 | UniProt (S5TF58) Pfam (PF00662) Pfam (PF00361) UniProt (by SIFTS) (Q9B6D3) | Yarrowia lipolytica | |
| 16 | P (6) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 185 | 20793.1 | 1 | UniProt (S5U3X7) Pfam (PF00499) UniProt (by SIFTS) (Q9B6E9) | Yarrowia lipolytica (Candida lipolytica) | |
| 17 | Q (g) | subunit NI9M of protein NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 78 | 8992.2 | 1 | UniProt (A0A1D8NJR0) UniProt (by SIFTS) (B5FVF3) | Yarrowia lipolytica | |
| 18 | R (D) | Subunit NIMM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 87 | 9806.2 | 1 | UniProt (A0A1D8NC63) Pfam (PF15879) UniProt (by SIFTS) (B5FVD3) | Yarrowia lipolytica (Candida lipolytica) | |
| 19 | S (E) | NADH-ubiquinone oxidoreductase 40 kDa subunit | polymer | 375 | 42765.7 | 1 | UniProt (A0A371BY45) Pfam (PF01370) UniProt (by SIFTS) (Q6C7X4) | Yarrowia lipolytica (Candida lipolytica) | |
| 20 | T (F) | Subunit NUFM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 144 | 16657.9 | 1 | UniProt (A0A371C5F3) Pfam (PF04716) UniProt (by SIFTS) (Q6C4W9) | Yarrowia lipolytica | |
| 21 | U (J) | Subunit NUJM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 198 | 20849.6 | 1 | UniProt (A0A371CB65) UniProt (by SIFTS) (Q6C674) | Yarrowia lipolytica | |
| 22 | V (M) | Subunit NUMM of protein NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 136 | 15149.0 | 1 | UniProt (A0A1H6Q8Z5) Pfam (PF10276) UniProt (by SIFTS) (Q6C8J9) | Yarrowia lipolytica (Candida lipolytica) | |
| 23 | W (O) | Acyl carrier protein ACPM1 of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 109 | 12053.6 | 1 | UniProt (A0A1H6PXT9) Pfam (PF00550) UniProt (by SIFTS) (Q6C926) | Yarrowia lipolytica (Candida lipolytica) | |
| 24 | X (P) | Subunit NB4M of protein NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 124 | 14778.8 | 1 | UniProt (A0A1D8N3C8) Pfam (PF13233) UniProt (by SIFTS) (Q6CI60) | Yarrowia lipolytica (Candida lipolytica) | |
| 25 | Y (Q) | Acyl carrier protein ACPM2 of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 132 | 14444.5 | 1 | UniProt (A0A1D8NG21) Pfam (PF00550) UniProt (by SIFTS) (Q6C7X2) | Yarrowia lipolytica (Candida lipolytica) | |
| 26 | Z (R) | Subunit NI2M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 109 | 12902.9 | 1 | UniProt (A0A1D8NDL1) UniProt (by SIFTS) (Q6C9Z1) | Yarrowia lipolytica (Candida lipolytica) | |
| 27 | AA (U) | Subunit NUPM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 172 | 19355.2 | 1 | UniProt (A0A371C2D0) Pfam (PF06747) UniProt (by SIFTS) (Q6CGB4) | Yarrowia lipolytica | |
| 28 | BA (W) | Subunit NB6M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 123 | 14112.4 | 1 | UniProt (A0A1H6PPE5) Pfam (PF06212) UniProt (by SIFTS) (B5FVF8) | Yarrowia lipolytica (Candida lipolytica) | |
| 29 | CA (X) | Subunit NUXM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 169 | 18588.2 | 1 | UniProt (A0A1D8NKB4) Pfam (PF10785) Pfam (PF12853) UniProt (by SIFTS) (Q6C4A6) | Yarrowia lipolytica (Candida lipolytica) | |
| 30 | DA (Y) | Subunit NUYM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 161 | 18656.1 | 1 | UniProt (A0A1D8N7X0) Pfam (PF04800) UniProt (by SIFTS) (Q6CEK9) | Yarrowia lipolytica (Candida lipolytica) | |
| 31 | EA (Z) | Subunit NUZM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 182 | 19772.5 | 1 | UniProt (A0A1D8N3H5) UniProt (by SIFTS) (Q6CI10) | Yarrowia lipolytica | |
| 32 | FA (a) | Subunit NIAM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 149 | 17328.5 | 1 | UniProt (A0A1D8ND94) Pfam (PF05821) UniProt (by SIFTS) (Q6CA88) | Yarrowia lipolytica | |
| 33 | GA (b) | Subunit NEBM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 74 | 8059.4 | 1 | UniProt (A0A1D8NGI5) | Yarrowia lipolytica | |
| 34 | HA (c) | Subunit NB2M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 60 | 6948.9 | 1 | UniProt (A0A371C0F2) Pfam (PF08122) UniProt (by SIFTS) (B5FVE5) | Yarrowia lipolytica | |
| 35 | IA (d) | Subunit NIDM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 92 | 11039.3 | 1 | UniProt (A0A1D8N596) Pfam (PF10249) UniProt (by SIFTS) (B5RSK3) | Yarrowia lipolytica (Candida lipolytica) | |
| 36 | JA (e) | Subunit NUVM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 67 | 7807.1 | 1 | UniProt (A0A1D8NFX6) | Yarrowia lipolytica | |
| 37 | KA (f) | Subunit NI8M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 87 | 9621.1 | 1 | UniProt (A0A1H6PJS3) Pfam (PF05047) UniProt (by SIFTS) (Q6CD73) | Yarrowia lipolytica (Candida lipolytica) | |
| 38 | LA (h) | Subunit N7BM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 138 | 16175.1 | 1 | UniProt (A0A1D8N5V2) Pfam (PF05071) UniProt (by SIFTS) (Q6CG53) | Yarrowia lipolytica | |
| 39 | MA (i) | Subunit NUUM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 90 | 9794.0 | 1 | UniProt (A0A1H6Q311) | Yarrowia lipolytica | |
| 40 | NA (n) | Subunit NUNM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 120 | 13523.1 | 1 | UniProt (A0A371CFV9) UniProt (by SIFTS) (Q6C1R9) | Yarrowia lipolytica (Candida lipolytica) | |
| 41 | OA (8) | Subunit NB8M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 99 | 11219.0 | 1 | UniProt (A0A1H6PKH9) Pfam (PF05676) UniProt (by SIFTS) (B5FVG1) | Yarrowia lipolytica (Candida lipolytica) | |
| 42 | PA (9) | Subunit NIPM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 89 | 10035.7 | 1 | UniProt (A0A1D8NNZ0) Pfam (PF10200) UniProt (by SIFTS) (B5RSL7) | Yarrowia lipolytica (Candida lipolytica) | |
| 43 | QA, RA, TA, WA, XA... (A, B, I, K) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 44 | SA, VA (A, H) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 45 | UA (B) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 46 | DB, GB, HC, OB, SB... (1, W, 4, 5, K) | DIUNDECYL PHOSPHATIDYL CHOLINE | non-polymer | 622.8 | 6 | Chemie (PLC) | |||
| 47 | AB, AC, CB, CC, DC... (S, J, 1, 4, b...) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 18 | Chemie (3PE) | |||
| 48 | BB, BC (j, J) | Lauryl Maltose Neopentyl Glycol | non-polymer | 1005.2 | 2 | Chemie (LMN) | |||
| 49 | HB, JB, KB (2, 3) | Phosphatidylinositol | non-polymer | 887.1 | 3 | Chemie (T7X) | |||
| 50 | IB (2) | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 758.1 | 1 | Chemie (CPL) | |||
| 51 | IC, JC, KC, MC, VB... (W, X, Z, n, g...) | CARDIOLIPIN | non-polymer | 1464.0 | 6 | Chemie (CDL) | |||
| 52 | XB (E) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 53 | EC (M) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 54 | FC, GC (O, Q) | S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate | non-polymer | 568.7 | 2 | Chemie (ZMP) | |||
| 55 | AD, BD, CD, DD, ED... (4, 5, 6, g, D...) | water | water | 18.0 | 1616 | Chemie (HOH) |
Sequence modifications
6: 2 - 185 (UniProt: S5U3X7)
| PDB | External Database | Details |
|---|---|---|
| Fme 1 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 42 |
| Total formula weight | 978842.0 | |
| Non-Polymers* | Number of molecules | 49 |
| Total formula weight | 36282.3 | |
| All* | Total formula weight | 1015124.3 |
