7O6Y
Cryo-EM structure of respiratory complex I under turnover
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Subunit NUAM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 728 | 79088.1 | 1 | UniProt (Q9UUU3) Pfam (PF13510) Pfam (PF10588) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) Pfam (PF09326) UniProt (by SIFTS) (F2Z6F1) | Yarrowia lipolytica (Candida lipolytica) | |
| 2 | B (B) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 488 | 53829.5 | 1 | UniProt (Q9UUU2) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) UniProt (by SIFTS) (F2Z660) | Yarrowia lipolytica (Candida lipolytica) | |
| 3 | C (C) | NUCM protein | polymer | 466 | 52521.9 | 1 | UniProt (Q9UUU1) Pfam (PF00346) UniProt (by SIFTS) (F2Z626) | Yarrowia lipolytica | |
| 4 | D (G) | Subunit NUGM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 281 | 32389.6 | 1 | UniProt (Q9UUU0) Pfam (PF00329) UniProt (by SIFTS) (F2Z6D7) | Yarrowia lipolytica (Candida lipolytica) | |
| 5 | E (H) | Subunit NUHM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 243 | 27247.4 | 1 | UniProt (Q9UUT9) Pfam (PF01257) UniProt (by SIFTS) (F2Z6C0) | Yarrowia lipolytica (Candida lipolytica) | |
| 6 | F (I) | Subunit NUIM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 229 | 25682.3 | 1 | UniProt (Q9UUT8) Pfam (PF12838) UniProt (by SIFTS) (F2Z619) | Yarrowia lipolytica (Candida lipolytica) | |
| 7 | G (K) | Subunit NUKM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 210 | 23455.2 | 1 | UniProt (Q9UUT7) Pfam (PF01058) UniProt (by SIFTS) (Q6C2Q1) | Yarrowia lipolytica (Candida lipolytica) | |
| 8 | H (L) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 89 | 9843.9 | 1 | UniProt (S5U4U1) Pfam (PF00420) UniProt (by SIFTS) (Q9B6D4) | Yarrowia lipolytica | |
| 9 | I (S) | Subunit NESM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 249 | 28479.9 | 1 | UniProt (Q6ZY23) UniProt (by SIFTS) (F2Z673) | Yarrowia lipolytica | |
| 10 | J (j) | Subunit NB5M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 93 | 10494.9 | 1 | UniProt (Q6ZY24) UniProt (by SIFTS) (B5RSK9) | Yarrowia lipolytica (Candida lipolytica) | |
| 11 | K (1) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 341 | 38389.3 | 1 | UniProt (S5U3V2) Pfam (PF00146) UniProt (by SIFTS) (Q9B6E8) | Yarrowia lipolytica | |
| 12 | L (2) | NADH dehydrogenase subunit 2 | polymer | 469 | 53381.4 | 1 | UniProt (S5U4R9) Pfam (PF00361) UniProt (by SIFTS) (Q9B6C8) | Yarrowia lipolytica | |
| 13 | M (3) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 128 | 14506.3 | 1 | UniProt (S5TMS4) Pfam (PF00507) UniProt (by SIFTS) (Q9B6C7) | Yarrowia lipolytica | |
| 14 | N (4) | Subunit NU4M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 486 | 54506.6 | 1 | UniProt (S5TMP9) Pfam (PF00361) UniProt (by SIFTS) (Q9B6D6) | Yarrowia lipolytica | |
| 15 | O (5) | Subunit NU5M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 655 | 73740.7 | 1 | UniProt (S5TF58) Pfam (PF00662) Pfam (PF00361) UniProt (by SIFTS) (Q9B6D3) | Yarrowia lipolytica | |
| 16 | P (6) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 185 | 20793.1 | 1 | UniProt (S5U3X7) Pfam (PF00499) UniProt (by SIFTS) (Q9B6E9) | Yarrowia lipolytica (Candida lipolytica) | |
| 17 | Q (g) | subunit NI9M of protein NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 78 | 8992.2 | 1 | UniProt (A0A1D8NJR0) UniProt (by SIFTS) (B5FVF3) | Yarrowia lipolytica | |
| 18 | R (D) | Subunit NIMM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 87 | 9806.2 | 1 | UniProt (A0A1D8NC63) Pfam (PF15879) UniProt (by SIFTS) (B5FVD3) | Yarrowia lipolytica (Candida lipolytica) | |
| 19 | S (E) | Subunit NUEM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 375 | 42765.7 | 1 | UniProt (A0A371BY45) Pfam (PF01370) UniProt (by SIFTS) (Q6C7X4) | Yarrowia lipolytica | |
| 20 | T (F) | Subunit NUFM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 144 | 16657.9 | 1 | UniProt (A0A371C5F3) Pfam (PF04716) UniProt (by SIFTS) (Q6C4W9) | Yarrowia lipolytica | |
| 21 | U (J) | Subunit NUJM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 198 | 20849.6 | 1 | UniProt (A0A371CB65) UniProt (by SIFTS) (Q6C674) | Yarrowia lipolytica | |
| 22 | V (M) | Subunit NUMM of protein NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 136 | 15149.0 | 1 | UniProt (A0A1H6Q8Z5) Pfam (PF10276) UniProt (by SIFTS) (Q6C8J9) | Yarrowia lipolytica (Candida lipolytica) | |
| 23 | W (O) | Acyl carrier protein ACPM1 of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 109 | 12053.6 | 1 | UniProt (A0A1H6PXT9) Pfam (PF00550) UniProt (by SIFTS) (Q6C926) | Yarrowia lipolytica (Candida lipolytica) | |
| 24 | X (P) | Subunit NB4M of protein NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 124 | 14778.8 | 1 | UniProt (A0A1D8N3C8) Pfam (PF13233) UniProt (by SIFTS) (Q6CI60) | Yarrowia lipolytica (Candida lipolytica) | |
| 25 | Y (Q) | Acyl carrier protein ACPM2 of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 132 | 14444.5 | 1 | UniProt (A0A1D8NG21) Pfam (PF00550) UniProt (by SIFTS) (Q6C7X2) | Yarrowia lipolytica (Candida lipolytica) | |
| 26 | Z (R) | Subunit NI2M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 109 | 12902.9 | 1 | UniProt (A0A1D8NDL1) UniProt (by SIFTS) (Q6C9Z1) | Yarrowia lipolytica (Candida lipolytica) | |
| 27 | AA (U) | Subunit NUPM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 172 | 19355.2 | 1 | UniProt (A0A371C2D0) Pfam (PF06747) UniProt (by SIFTS) (Q6CGB4) | Yarrowia lipolytica | |
| 28 | BA (W) | Subunit NB6M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 123 | 14112.4 | 1 | UniProt (A0A1H6PPE5) Pfam (PF06212) UniProt (by SIFTS) (B5FVF8) | Yarrowia lipolytica (Candida lipolytica) | |
| 29 | CA (X) | Subunit NUXM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 169 | 18588.2 | 1 | UniProt (A0A1D8NKB4) Pfam (PF10785) Pfam (PF12853) UniProt (by SIFTS) (Q6C4A6) | Yarrowia lipolytica (Candida lipolytica) | |
| 30 | DA (Y) | Subunit NUYM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 161 | 18656.1 | 1 | UniProt (A0A1D8N7X0) Pfam (PF04800) UniProt (by SIFTS) (Q6CEK9) | Yarrowia lipolytica (Candida lipolytica) | |
| 31 | EA (Z) | Subunit NUZM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 182 | 19772.5 | 1 | UniProt (A0A1D8N3H5) UniProt (by SIFTS) (Q6CI10) | Yarrowia lipolytica | |
| 32 | FA (a) | Subunit NIAM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 149 | 17328.5 | 1 | UniProt (A0A1D8ND94) Pfam (PF05821) UniProt (by SIFTS) (Q6CA88) | Yarrowia lipolytica | |
| 33 | GA (b) | Subunit NEBM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 74 | 8059.4 | 1 | UniProt (A0A1D8NGI5) | Yarrowia lipolytica | |
| 34 | HA (c) | Subunit NB2M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 60 | 6948.9 | 1 | UniProt (A0A371C0F2) Pfam (PF08122) UniProt (by SIFTS) (B5FVE5) | Yarrowia lipolytica | |
| 35 | IA (d) | Subunit NIDM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 92 | 11039.3 | 1 | UniProt (A0A1D8N596) Pfam (PF10249) UniProt (by SIFTS) (B5RSK3) | Yarrowia lipolytica (Candida lipolytica) | |
| 36 | JA (e) | Subunit NUVM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 67 | 7807.1 | 1 | UniProt (A0A1D8NFX6) | Yarrowia lipolytica | |
| 37 | KA (f) | Subunit NI8M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 87 | 9621.1 | 1 | UniProt (A0A1H6PJS3) Pfam (PF05047) UniProt (by SIFTS) (Q6CD73) | Yarrowia lipolytica (Candida lipolytica) | |
| 38 | LA (h) | Subunit N7BM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 138 | 16175.1 | 1 | UniProt (A0A1D8N5V2) Pfam (PF05071) UniProt (by SIFTS) (Q6CG53) | Yarrowia lipolytica | |
| 39 | MA (i) | Subunit NUUM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 90 | 9794.0 | 1 | UniProt (A0A1H6Q311) | Yarrowia lipolytica | |
| 40 | NA (n) | Subunit NUNM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 139 | 15818.8 | 1 | UniProt (A0A371CFV9) UniProt (by SIFTS) (Q6C1R9) | Yarrowia lipolytica (Candida lipolytica) | |
| 41 | OA (8) | Subunit NB8M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 99 | 11219.0 | 1 | UniProt (A0A1H6PKH9) Pfam (PF05676) UniProt (by SIFTS) (B5FVG1) | Yarrowia lipolytica (Candida lipolytica) | |
| 42 | PA (9) | Subunit NIPM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 89 | 10035.7 | 1 | UniProt (A0A1D8NNZ0) Pfam (PF10200) UniProt (by SIFTS) (B5RSL7) | Yarrowia lipolytica (Candida lipolytica) | |
| 43 | AB, BB, QA, RA, TA... (I, K, A, B) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 44 | SA, XA (A, H) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 45 | UA (B) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) PubChem (23585816) PubChem (51435500) PubChem (51435503) PubChem (15559251) PubChem (710) PubChem (8965) PubChem (643976) PubChem (5702760) PubChem (7048779) PubChem (7048781) | |||
| 46 | VA (B) | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 1 | Chemie (NAI) PubChem (16219774) PubChem (44119956) PubChem (44415182) PubChem (439153) PubChem (124934832) PubChem (126455899) PubChem (134693949) PubChem (12309339) PubChem (12309347) PubChem (140875346) PubChem (162951601) PubChem (162951600) PubChem (164575491) PubChem (169545638) PubChem (170905224) PubChem (174316169) PubChem (94865921) PubChem (94865923) PubChem (928) PubChem (124432988) PubChem (124934831) PubChem (124934833) PubChem (11250888) PubChem (129607000) PubChem (129628338) PubChem (12309341) PubChem (146167236) PubChem (162951602) PubChem (174084875) | |||
| 47 | WA (C) | Ubiquinone-9 | non-polymer | 795.2 | 1 | Chemie (UQ9) PubChem (5280473) PubChem (97038296) PubChem (97038294) PubChem (97038295) PubChem (99490) PubChem (125181414) PubChem (137350099) | |||
| 48 | EB, FB, JB, KC, LB... (1, 2, b, 4, 5...) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 16 | Chemie (3PE) | |||
| 49 | CB, DB, EC, GB, LC... (K, 1, W, i, 4) | DIUNDECYL PHOSPHATIDYL CHOLINE | non-polymer | 622.8 | 6 | Chemie (PLC) PubChem (65263) PubChem (87507) PubChem (445355) | |||
| 50 | HB (2) | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 758.1 | 1 | Chemie (CPL) PubChem (16213884) PubChem (122218) PubChem (46936342) PubChem (5287971) PubChem (6021688) PubChem (6438359) PubChem (131706484) PubChem (14389437) | |||
| 51 | IB, JC, KB (2, b, 3) | Phosphatidylinositol | non-polymer | 887.1 | 3 | Chemie (T7X) PubChem (21226108) PubChem (42607491) PubChem (174696) PubChem (72280035) PubChem (101025742) PubChem (101668931) PubChem (102207642) PubChem (10260108) PubChem (134744895) PubChem (154815683) PubChem (162368813) PubChem (59423079) PubChem (71581204) PubChem (123819699) PubChem (6441989) PubChem (137350037) PubChem (162371041) PubChem (172878298) | |||
| 52 | FC, GC, HC, MC, UB... (W, X, Z, n, g...) | CARDIOLIPIN | non-polymer | 1464.0 | 6 | Chemie (CDL) PubChem (17753886) PubChem (5287898) | |||
| 53 | WB (E) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 54 | AC, IC (J, a) | Lauryl Maltose Neopentyl Glycol | non-polymer | 1005.2 | 2 | Chemie (LMN) PubChem (49839603) PubChem (70678409) PubChem (75300949) PubChem (132285124) PubChem (153502978) PubChem (172914192) PubChem (126731017) | |||
| 55 | BC (M) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 56 | CC, DC (O, Q) | S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate | non-polymer | 568.7 | 2 | Chemie (ZMP) PubChem (24941266) PubChem (74369227) PubChem (119058172) |
Sequence modifications
6: 2 - 185 (UniProt: S5U3X7)
| PDB | External Database | Details |
|---|---|---|
| Fme 1 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 42 |
| Total formula weight | 981081.7 | |
| Non-Polymers* | Number of molecules | 49 |
| Total formula weight | 36246.9 | |
| All* | Total formula weight | 1017328.5 |
