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7O6Y

Cryo-EM structure of respiratory complex I under turnover

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ASubunit NUAM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer72879088.11UniProt (Q9UUU3)
Pfam (PF13510)
Pfam (PF10588)
Pfam (PF22117)
Pfam (PF22151)
Pfam (PF00384)
Pfam (PF09326)
UniProt (by SIFTS) (F2Z6F1)
In PDB		Yarrowia lipolytica (Candida lipolytica)
2BNADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialpolymer48853829.51UniProt (Q9UUU2)
Pfam (PF01512)
Pfam (PF22461)
Pfam (PF10589)
UniProt (by SIFTS) (F2Z660)
In PDB		Yarrowia lipolytica (Candida lipolytica)
3CNUCM proteinpolymer46652521.91UniProt (Q9UUU1)
Pfam (PF00346)
UniProt (by SIFTS) (F2Z626)
In PDB		Yarrowia lipolytica
4GSubunit NUGM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer28132389.61UniProt (Q9UUU0)
Pfam (PF00329)
UniProt (by SIFTS) (F2Z6D7)
In PDB		Yarrowia lipolytica (Candida lipolytica)
5HSubunit NUHM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer24327247.41UniProt (Q9UUT9)
Pfam (PF01257)
UniProt (by SIFTS) (F2Z6C0)
In PDB		Yarrowia lipolytica (Candida lipolytica)
6ISubunit NUIM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer22925682.31UniProt (Q9UUT8)
Pfam (PF12838)
UniProt (by SIFTS) (F2Z619)
In PDB		Yarrowia lipolytica (Candida lipolytica)
7KSubunit NUKM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer21023455.21UniProt (Q9UUT7)
Pfam (PF01058)
UniProt (by SIFTS) (Q6C2Q1)
In PDB		Yarrowia lipolytica (Candida lipolytica)
8LNADH-ubiquinone oxidoreductase chain 4Lpolymer899843.91UniProt (S5U4U1)
Pfam (PF00420)
UniProt (by SIFTS) (Q9B6D4)
In PDB		Yarrowia lipolytica
9SSubunit NESM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer24928479.91UniProt (Q6ZY23)
UniProt (by SIFTS) (F2Z673)
In PDB		Yarrowia lipolytica
10jSubunit NB5M of NADH:Ubiquinone Oxidoreductase (Complex I)polymer9310494.91UniProt (Q6ZY24)
UniProt (by SIFTS) (B5RSK9)
In PDB		Yarrowia lipolytica (Candida lipolytica)
111NADH-ubiquinone oxidoreductase chain 1polymer34138389.31UniProt (S5U3V2)
Pfam (PF00146)
UniProt (by SIFTS) (Q9B6E8)
In PDB		Yarrowia lipolytica
122NADH dehydrogenase subunit 2polymer46953381.41UniProt (S5U4R9)
Pfam (PF00361)
UniProt (by SIFTS) (Q9B6C8)
In PDB		Yarrowia lipolytica
133NADH-ubiquinone oxidoreductase chain 3polymer12814506.31UniProt (S5TMS4)
Pfam (PF00507)
UniProt (by SIFTS) (Q9B6C7)
In PDB		Yarrowia lipolytica
144Subunit NU4M of NADH:Ubiquinone Oxidoreductase (Complex I)polymer48654506.61UniProt (S5TMP9)
Pfam (PF00361)
UniProt (by SIFTS) (Q9B6D6)
In PDB		Yarrowia lipolytica
155Subunit NU5M of NADH:Ubiquinone Oxidoreductase (Complex I)polymer65573740.71UniProt (S5TF58)
Pfam (PF00662)
Pfam (PF00361)
UniProt (by SIFTS) (Q9B6D3)
In PDB		Yarrowia lipolytica
166NADH-ubiquinone oxidoreductase chain 6polymer18520793.11UniProt (S5U3X7)
Pfam (PF00499)
UniProt (by SIFTS) (Q9B6E9)
In PDB		Yarrowia lipolytica (Candida lipolytica)
17gsubunit NI9M of protein NADH:Ubiquinone Oxidoreductase (Complex I)polymer788992.21UniProt (A0A1D8NJR0)
UniProt (by SIFTS) (B5FVF3)
In PDB		Yarrowia lipolytica
18DSubunit NIMM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer879806.21UniProt (A0A1D8NC63)
Pfam (PF15879)
UniProt (by SIFTS) (B5FVD3)
In PDB		Yarrowia lipolytica (Candida lipolytica)
19ESubunit NUEM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer37542765.71UniProt (A0A371BY45)
Pfam (PF01370)
UniProt (by SIFTS) (Q6C7X4)
In PDB		Yarrowia lipolytica
20FSubunit NUFM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer14416657.91UniProt (A0A371C5F3)
Pfam (PF04716)
UniProt (by SIFTS) (Q6C4W9)
In PDB		Yarrowia lipolytica
21JSubunit NUJM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer19820849.61UniProt (A0A371CB65)
UniProt (by SIFTS) (Q6C674)
In PDB		Yarrowia lipolytica
22MSubunit NUMM of protein NADH:Ubiquinone Oxidoreductase (Complex I)polymer13615149.01UniProt (A0A1H6Q8Z5)
Pfam (PF10276)
UniProt (by SIFTS) (Q6C8J9)
In PDB		Yarrowia lipolytica (Candida lipolytica)
23OAcyl carrier protein ACPM1 of NADH:Ubiquinone Oxidoreductase (Complex I)polymer10912053.61UniProt (A0A1H6PXT9)
Pfam (PF00550)
UniProt (by SIFTS) (Q6C926)
In PDB		Yarrowia lipolytica (Candida lipolytica)
24PSubunit NB4M of protein NADH:Ubiquinone Oxidoreductase (Complex I)polymer12414778.81UniProt (A0A1D8N3C8)
Pfam (PF13233)
UniProt (by SIFTS) (Q6CI60)
In PDB		Yarrowia lipolytica (Candida lipolytica)
25QAcyl carrier protein ACPM2 of NADH:Ubiquinone Oxidoreductase (Complex I)polymer13214444.51UniProt (A0A1D8NG21)
Pfam (PF00550)
UniProt (by SIFTS) (Q6C7X2)
In PDB		Yarrowia lipolytica (Candida lipolytica)
26RSubunit NI2M of NADH:Ubiquinone Oxidoreductase (Complex I)polymer10912902.91UniProt (A0A1D8NDL1)
UniProt (by SIFTS) (Q6C9Z1)
In PDB		Yarrowia lipolytica (Candida lipolytica)
27USubunit NUPM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer17219355.21UniProt (A0A371C2D0)
Pfam (PF06747)
UniProt (by SIFTS) (Q6CGB4)
In PDB		Yarrowia lipolytica
28WSubunit NB6M of NADH:Ubiquinone Oxidoreductase (Complex I)polymer12314112.41UniProt (A0A1H6PPE5)
Pfam (PF06212)
UniProt (by SIFTS) (B5FVF8)
In PDB		Yarrowia lipolytica (Candida lipolytica)
29XSubunit NUXM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer16918588.21UniProt (A0A1D8NKB4)
Pfam (PF10785)
Pfam (PF12853)
UniProt (by SIFTS) (Q6C4A6)
In PDB		Yarrowia lipolytica (Candida lipolytica)
30YSubunit NUYM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer16118656.11UniProt (A0A1D8N7X0)
Pfam (PF04800)
UniProt (by SIFTS) (Q6CEK9)
In PDB		Yarrowia lipolytica (Candida lipolytica)
31ZSubunit NUZM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer18219772.51UniProt (A0A1D8N3H5)
UniProt (by SIFTS) (Q6CI10)
In PDB		Yarrowia lipolytica
32aSubunit NIAM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer14917328.51UniProt (A0A1D8ND94)
Pfam (PF05821)
UniProt (by SIFTS) (Q6CA88)
In PDB		Yarrowia lipolytica
33bSubunit NEBM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer748059.41UniProt (A0A1D8NGI5)
In PDB		Yarrowia lipolytica
34cSubunit NB2M of NADH:Ubiquinone Oxidoreductase (Complex I)polymer606948.91UniProt (A0A371C0F2)
Pfam (PF08122)
UniProt (by SIFTS) (B5FVE5)
In PDB		Yarrowia lipolytica
35dSubunit NIDM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer9211039.31UniProt (A0A1D8N596)
Pfam (PF10249)
UniProt (by SIFTS) (B5RSK3)
In PDB		Yarrowia lipolytica (Candida lipolytica)
36eSubunit NUVM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer677807.11UniProt (A0A1D8NFX6)
In PDB		Yarrowia lipolytica
37fSubunit NI8M of NADH:Ubiquinone Oxidoreductase (Complex I)polymer879621.11UniProt (A0A1H6PJS3)
Pfam (PF05047)
UniProt (by SIFTS) (Q6CD73)
In PDB		Yarrowia lipolytica (Candida lipolytica)
38hSubunit N7BM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer13816175.11UniProt (A0A1D8N5V2)
Pfam (PF05071)
UniProt (by SIFTS) (Q6CG53)
In PDB		Yarrowia lipolytica
39iSubunit NUUM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer909794.01UniProt (A0A1H6Q311)
In PDB		Yarrowia lipolytica
40nSubunit NUNM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer13915818.81UniProt (A0A371CFV9)
UniProt (by SIFTS) (Q6C1R9)
In PDB		Yarrowia lipolytica (Candida lipolytica)
418Subunit NB8M of NADH:Ubiquinone Oxidoreductase (Complex I)polymer9911219.01UniProt (A0A1H6PKH9)
Pfam (PF05676)
UniProt (by SIFTS) (B5FVG1)
In PDB		Yarrowia lipolytica (Candida lipolytica)
429Subunit NIPM of NADH:Ubiquinone Oxidoreductase (Complex I)polymer8910035.71UniProt (A0A1D8NNZ0)
Pfam (PF10200)
UniProt (by SIFTS) (B5RSL7)
In PDB		Yarrowia lipolytica (Candida lipolytica)
43I, K, A, BIRON/SULFUR CLUSTERnon-polymer351.66Chemie (SF4)
44A, HFE2/S2 (INORGANIC) CLUSTERnon-polymer175.82Chemie (FES)
45BFLAVIN MONONUCLEOTIDEnon-polymer456.31Chemie (FMN)
46B1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDEnon-polymer665.41Chemie (NAI)
47CUbiquinone-9non-polymer795.21Chemie (UQ9)
481, 2, b, 4, 5...1,2-Distearoyl-sn-glycerophosphoethanolaminenon-polymer748.116Chemie (3PE)
49K, 1, W, i, 4DIUNDECYL PHOSPHATIDYL CHOLINEnon-polymer622.86Chemie (PLC)
5021-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINEnon-polymer758.11Chemie (CPL)
512, b, 3Phosphatidylinositolnon-polymer887.13Chemie (T7X)
52W, X, Z, n, g...CARDIOLIPINnon-polymer1464.06Chemie (CDL)
53ENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer745.41Chemie (NDP)
54J, aLauryl Maltose Neopentyl Glycolnon-polymer1005.22Chemie (LMN)
55MZINC IONnon-polymer65.41Chemie (ZN)
56O, RS-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioatenon-polymer568.72Chemie (ZMP)
Sequence modifications
6: 2 - 185 (UniProt: S5U3X7)
PDBExternal DatabaseDetails
Fme 1-insertion
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains42
Total formula weight981081.7
Non-Polymers*Number of molecules49
Total formula weight36246.9
All*Total formula weight1017328.5
*Water molecules are not included.

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PDB entries from 2024-10-02

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