7O2I
METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM2457
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | N6-adenosine-methyltransferase catalytic subunit | polymer | 228 | 26017.8 | 1 | UniProt (Q86U44) Pfam (PF05063) In PDB | Homo sapiens (Human) | Methyltransferase-like protein 3,hMETTL3,N6-adenosine-methyltransferase 70 kDa subunit,MT-A70 |
| 2 | B | N6-adenosine-methyltransferase non-catalytic subunit | polymer | 291 | 33634.2 | 1 | UniProt (Q9HCE5) Pfam (PF05063) In PDB | Homo sapiens (Human) | Methyltransferase-like protein 14,hMETTL14 |
| 3 | A | ~{N}-[[6-[(cyclohexylmethylamino)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxidanylidene-1~{H}-pyrido[1,2-a]pyrimidine-2-carboxamide | non-polymer | 445.5 | 1 | Chemie (V22) | |||
| 4 | B | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A: 354 - 580 (UniProt: Q86U44)
B: 107 - 395 (UniProt: Q9HCE5)
| PDB | External Database | Details |
|---|---|---|
| Met 353 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly 105 | - | expression tag |
| Ser 106 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59652.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 523.7 | |
| All* | Total formula weight | 60175.7 |
