7NZW
Crystal structure of chimeric carbonic anhydrase VA with 4-[(4,6-dimethylpyrimidin-2-yl)thio]-2,3,5,6-tetrafluorobenzenesulfonamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Carbonic anhydrase 2 | polymer | 260 | 29377.2 | 1 | UniProt (P00918) Pfam (PF00194) In PDB | Homo sapiens (Human) | Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | 4-[(4,6-dimethylpyrimidin-2-yl)thio]-2,3,5,6-tetrafluorobenzenesulfonamide | non-polymer | 367.3 | 1 | Chemie (V50) | |||
4 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
5 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
6 | water | water | 18.0 | 261 | Chemie (HOH) |
Sequence modifications
A: 1 - 260 (UniProt: P00918)
PDB | External Database | Details |
---|---|---|
Thr 62 | Asn 62 | engineered mutation |
Tyr 64 | His 64 | engineered mutation |
Leu 65 | Ala 65 | engineered mutation |
Gln 67 | Asn 67 | engineered mutation |
Lys 91 | Ile 91 | engineered mutation |
Tyr 130 | Phe 130 | engineered mutation |
Thr 203 | Leu 203 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 29377.2 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 533.9 | |
All* | Total formula weight | 29911.0 |