7NVR
Human Mediator with RNA Polymerase II Pre-initiation complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | 0 | TFIIH basal transcription factor complex helicase XPD subunit | polymer | 760 | 87021.1 | 1 | UniProt (P18074) Pfam (PF06733) Pfam (PF06777) Pfam (PF13307) In PDB | Homo sapiens (Human) | Basic transcription factor 2 80 kDa subunit,BTF2 p80,CXPD,DNA excision repair protein ERCC-2,DNA repair protein complementing XP-D cells,TFIIH basal transcription factor complex 80 kDa subunit,TFIIH p80,Xeroderma pigmentosum group D-complementing protein |
| 2 | 1 | General transcription factor IIH subunit 1 | polymer | 548 | 62116.5 | 1 | UniProt (P32780) Pfam (PF08567) Pfam (PF03909) In PDB | Homo sapiens (Human) | Basic transcription factor 2 62 kDa subunit,BTF2 p62,General transcription factor IIH polypeptide 1,TFIIH basal transcription factor complex p62 subunit |
| 3 | 2 | General transcription factor IIH subunit 4 | polymer | 462 | 52245.2 | 1 | UniProt (Q92759) Pfam (PF03849) Pfam (PF18307) In PDB | Homo sapiens (Human) | Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,TFIIH basal transcription factor complex p52 subunit |
| 4 | 3 | CDK-activating kinase assembly factor MAT1 | polymer | 309 | 35874.0 | 1 | UniProt (P51948) Pfam (PF17121) Pfam (PF06391) In PDB | Homo sapiens (Human) | CDK7/cyclin-H assembly factor,Cyclin-G1-interacting protein,Menage a trois,RING finger protein 66,RING finger protein MAT1,p35,p36 |
| 5 | 4 | General transcription factor IIH subunit 3 | polymer | 308 | 34416.0 | 1 | UniProt (Q13889) Pfam (PF03850) In PDB | Homo sapiens (Human) | Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,TFIIH basal transcription factor complex p34 subunit |
| 6 | 5 | General transcription factor IIH subunit 5 | polymer | 71 | 8060.4 | 1 | UniProt (Q6ZYL4) Pfam (PF06331) In PDB | Homo sapiens (Human) | General transcription factor IIH polypeptide 5,TFB5 ortholog,TFIIH basal transcription factor complex TTD-A subunit |
| 7 | 6 | General transcription factor IIH subunit 2 | polymer | 395 | 44482.0 | 1 | UniProt (Q13888) Pfam (PF04056) Pfam (PF07975) In PDB | Homo sapiens (Human) | Basic transcription factor 2 44 kDa subunit,BTF2 p44,General transcription factor IIH polypeptide 2,TFIIH basal transcription factor complex p44 subunit |
| 8 | 7 | General transcription and DNA repair factor IIH helicase subunit XPB | polymer | 782 | 89404.7 | 1 | UniProt (P19447) Pfam (PF13625) Pfam (PF04851) Pfam (PF16203) In PDB | Homo sapiens (Human) | TFIIH subunit XPB,Basic transcription factor 2 89 kDa subunit,BTF2 p89,DNA excision repair protein ERCC-3,DNA repair protein complementing XP-B cells,TFIIH basal transcription factor complex 89 kDa subunit,TFIIH p89,Xeroderma pigmentosum group B-complementing protein |
| 9 | 8 | Cyclin-dependent kinase 7 | polymer | 346 | 39090.3 | 1 | UniProt (P50613) Pfam (PF00069) In PDB | Homo sapiens (Human) | 39 kDa protein kinase,p39 Mo15,CDK-activating kinase 1,Cell division protein kinase 7,Serine/threonine-protein kinase 1,TFIIH basal transcription factor complex kinase subunit |
| 10 | 9 | Cyclin-H | polymer | 323 | 37695.5 | 1 | UniProt (P51946) Pfam (PF00134) Pfam (PF16899) In PDB | Homo sapiens (Human) | MO15-associated protein,p34,p37 |
| 11 | A | DNA-directed RNA polymerase subunit | polymer | 1970 | 217450.1 | 1 | Pfam (PF04997) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) Pfam (PF04992) Pfam (PF04990) Pfam (PF05001) UniProt (by SIFTS) (A0A7M4DUC2) In PDB | Sus scrofa (Pig) | |
| 12 | B | DNA-directed RNA polymerase subunit beta | polymer | 1174 | 134041.4 | 1 | UniProt (I3LGP4) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF04566) Pfam (PF04567) Pfam (PF00562) Pfam (PF04560) In PDB | Sus scrofa (Pig) | |
| 13 | C | DNA-directed RNA polymerase II subunit RPB3 | polymer | 275 | 31439.1 | 1 | UniProt (I3LCH3) Pfam (PF01193) Pfam (PF01000) In PDB | Sus scrofa (Pig) | |
| 14 | D | RPOL4c domain-containing protein | polymer | 142 | 16331.3 | 1 | UniProt (A0A287ADR4) Pfam (PF03874) In PDB | Sus scrofa (Pig) | |
| 15 | E | DNA-directed RNA polymerase II subunit E | polymer | 210 | 24644.3 | 1 | UniProt (I3LSI7) Pfam (PF03871) Pfam (PF01191) In PDB | Sus scrofa (Pig) | RPB5 homolog |
| 16 | F | DNA-directed RNA polymerase II subunit F | polymer | 127 | 14477.0 | 1 | UniProt (F1SKN8) Pfam (PF01192) UniProt (by SIFTS) (A0A4X1VEK9) In PDB | Sus scrofa (Pig) | DNA-directed RNA polymerases I,II,and III subunit RPABC2,RPB6 homolog |
| 17 | G | DNA-directed RNA polymerase II subunit RPB7 | polymer | 172 | 19314.3 | 1 | UniProt (I3LJZ9) In PDB | Sus scrofa (Pig) | |
| 18 | H | DNA-directed RNA polymerases I, II, and III subunit RPABC3 | polymer | 150 | 17162.3 | 1 | UniProt (A0A4X1ULF2) Pfam (PF03870) UniProt (by SIFTS) (I3LCB2) In PDB | Sus scrofa (Pig) | |
| 19 | I | DNA-directed RNA polymerase II subunit RPB9 | polymer | 125 | 14541.2 | 1 | UniProt (P60899) Pfam (PF02150) Pfam (PF01096) In PDB | Sus scrofa (Pig) | RNA polymerase II subunit B9,DNA-directed RNA polymerase II subunit I,RNA polymerase II 14.5 kDa subunit,RPB14.5 |
| 20 | J | DNA-directed RNA polymerases I, II, and III subunit RPABC5 | polymer | 67 | 7655.1 | 1 | UniProt (A0A4X1VYD0) Pfam (PF01194) In PDB | Sus scrofa (Pig) | |
| 21 | K | RNA_pol_L_2 domain-containing protein | polymer | 117 | 13310.3 | 1 | UniProt (A0A4X1UK25) Pfam (PF13656) UniProt (by SIFTS) (F1RKE4) In PDB | Sus scrofa (Pig) | |
| 22 | L | RNA polymerase II subunit K | polymer | 58 | 7018.2 | 1 | UniProt (I3LN51) Pfam (PF03604) UniProt (by SIFTS) (A0A4X1TRS6) In PDB | Sus scrofa (Pig) | |
| 23 | M | Transcription initiation factor IIB | polymer | 316 | 34877.9 | 1 | UniProt (Q00403) Pfam (PF08271) Pfam (PF00382) In PDB | Homo sapiens (Human) | General transcription factor TFIIB,S300-II |
| 24 | N | NT | polymer | 106 | 32911.9 | 1 | GenBank (1706691521) | Human mastadenovirus C | |
| 25 | O | TATA-box-binding protein | polymer | 339 | 37729.9 | 1 | UniProt (P20226) Pfam (PF00352) In PDB | Homo sapiens (Human) | TATA sequence-binding protein,TATA-binding factor,TATA-box factor,Transcription initiation factor TFIID TBP subunit |
| 26 | Q | General transcription factor IIF subunit 1 | polymer | 517 | 58343.6 | 1 | UniProt (P35269) Pfam (PF05793) In PDB | Homo sapiens (Human) | General transcription factor IIF 74 kDa subunit,Transcription initiation factor IIF subunit alpha,TFIIF-alpha,Transcription initiation factor RAP74 |
| 27 | R | General transcription factor IIF subunit 2 | polymer | 249 | 28427.3 | 1 | UniProt (P13984) Pfam (PF17683) Pfam (PF02270) In PDB | Homo sapiens (Human) | ATP-dependent helicase GTF2F2,General transcription factor IIF 30 kDa subunit,Transcription initiation factor IIF subunit beta,TFIIF-beta,Transcription initiation factor RAP30 |
| 28 | T | TEMPLATE | polymer | 106 | 32508.8 | 1 | GenBank (1706691521) | Human mastadenovirus C | |
| 29 | U | Transcription initiation factor IIA subunit 1 | polymer | 376 | 41544.6 | 1 | UniProt (P52655) Pfam (PF03153) In PDB | Homo sapiens (Human) | General transcription factor IIA subunit 1,TFIIAL,Transcription initiation factor TFIIA 42 kDa subunit,TFIIA-42 |
| 30 | V | Transcription initiation factor IIA subunit 2 | polymer | 109 | 12469.1 | 1 | UniProt (P52657) Pfam (PF02268) Pfam (PF02751) In PDB | Homo sapiens (Human) | General transcription factor IIA subunit 2,TFIIA p12 subunit,TFIIA-12,TFIIAS,Transcription initiation factor IIA gamma chain,TFIIA-gamma |
| 31 | W | General transcription factor IIE subunit 1 | polymer | 439 | 49516.1 | 1 | UniProt (P29083) Pfam (PF02002) Pfam (PF08271) Pfam (PF11521) In PDB | Homo sapiens (Human) | General transcription factor IIE 56 kDa subunit,Transcription initiation factor IIE subunit alpha,TFIIE-alpha |
| 32 | X | Transcription initiation factor IIE subunit beta | polymer | 291 | 33106.8 | 1 | UniProt (P29084) Pfam (PF02186) Pfam (PF18121) In PDB | Homo sapiens (Human) | TFIIE-beta,General transcription factor IIE subunit 2 |
| 33 | Y | Unassigned peptide, likely TFIIE-beta | polymer | 19 | 1635.0 | 1 | Homo sapiens (Human) | ||
| 34 | Z | Unassigned peptide, likely XPB | polymer | 8 | 698.9 | 1 | Homo sapiens (Human) | ||
| 35 | a | Mediator of RNA polymerase II transcription subunit 6 | polymer | 246 | 28464.6 | 1 | UniProt (O75586) Pfam (PF04934) In PDB | Homo sapiens (Human) | Activator-recruited cofactor 33 kDa component,ARC33,Mediator complex subunit 6,hMed6,Renal carcinoma antigen NY-REN-28 |
| 36 | b | Mediator of RNA polymerase II transcription subunit 8 | polymer | 268 | 29112.9 | 1 | UniProt (Q96G25) Pfam (PF10232) In PDB | Homo sapiens (Human) | Activator-recruited cofactor 32 kDa component,ARC32,Mediator complex subunit 8 |
| 37 | c | Mediator of RNA polymerase II transcription subunit 11 | polymer | 117 | 13145.8 | 1 | UniProt (Q9P086) Pfam (PF10280) In PDB | Homo sapiens (Human) | Mediator complex subunit 11 |
| 38 | d | Mediator of RNA polymerase II transcription subunit 17 | polymer | 651 | 72984.0 | 1 | UniProt (Q9NVC6) Pfam (PF10156) In PDB | Homo sapiens (Human) | Activator-recruited cofactor 77 kDa component,ARC77,Cofactor required for Sp1 transcriptional activation subunit 6,CRSP complex subunit 6,Mediator complex subunit 17,Thyroid hormone receptor-associated protein complex 80 kDa component,Trap80,Transcriptional coactivator CRSP77,Vitamin D3 receptor-interacting protein complex 80 kDa component,DRIP80 |
| 39 | e | Mediator of RNA polymerase II transcription subunit 18 | polymer | 208 | 23693.7 | 1 | UniProt (Q9BUE0) Pfam (PF09637) In PDB | Homo sapiens (Human) | Mediator complex subunit 18,p28b |
| 40 | f | Mediator of RNA polymerase II transcription subunit 20 | polymer | 212 | 23243.8 | 1 | UniProt (Q9H944) Pfam (PF08612) In PDB | Homo sapiens (Human) | Mediator complex subunit 20,TRF-proximal protein homolog,hTRFP |
| 41 | g | Mediator of RNA polymerase II transcription subunit 22 | polymer | 200 | 22243.7 | 1 | UniProt (Q15528) Pfam (PF06179) In PDB | Homo sapiens (Human) | Mediator complex subunit 22,Surfeit locus protein 5,Surf-5 |
| 42 | h | Mediator of RNA polymerase II transcription subunit 4 | polymer | 270 | 29781.4 | 1 | UniProt (Q9NPJ6) Pfam (PF10018) In PDB | Homo sapiens (Human) | Activator-recruited cofactor 36 kDa component,ARC36,Mediator complex subunit 4,TRAP/SMCC/PC2 subunit p36 subunit,Vitamin D3 receptor-interacting protein complex 36 kDa component,DRIP36 |
| 43 | i | Mediator of RNA polymerase II transcription subunit 7 | polymer | 233 | 27285.3 | 1 | UniProt (O43513) Pfam (PF05983) In PDB | Homo sapiens (Human) | hMED7,Activator-recruited cofactor 34 kDa component,ARC34,Cofactor required for Sp1 transcriptional activation subunit 9,CRSP complex subunit 9,Mediator complex subunit 7,RNA polymerase transcriptional regulation mediator subunit 7 homolog,Transcriptional coactivator CRSP33 |
| 44 | j | Mediator of RNA polymerase II transcription subunit 9 | polymer | 146 | 16422.8 | 1 | UniProt (Q9NWA0) Pfam (PF07544) In PDB | Homo sapiens (Human) | Mediator complex subunit 9 |
| 45 | k | Mediator of RNA polymerase II transcription subunit 10 | polymer | 135 | 15711.0 | 1 | UniProt (Q9BTT4) Pfam (PF09748) In PDB | Homo sapiens (Human) | Mediator complex subunit 10,Transformation-related gene 17 protein,TRG-17,Transformation-related gene 20 protein,TRG-20 |
| 46 | l | Mediator of RNA polymerase II transcription subunit 14 | polymer | 1454 | 160787.6 | 1 | UniProt (O60244) Pfam (PF08638) Pfam (PF22981) Pfam (PF22984) Pfam (PF22983) In PDB | Homo sapiens (Human) | Activator-recruited cofactor 150 kDa component,ARC150,Cofactor required for Sp1 transcriptional activation subunit 2,CRSP complex subunit 2,Mediator complex subunit 14,RGR1 homolog,hRGR1,Thyroid hormone receptor-associated protein complex 170 kDa component,Trap170,Transcriptional coactivator CRSP150,Vitamin D3 receptor-interacting protein complex 150 kDa component,DRIP150 |
| 47 | m | Mediator of RNA polymerase II transcription subunit 19 | polymer | 244 | 26321.1 | 1 | UniProt (A0JLT2) Pfam (PF10278) In PDB | Homo sapiens (Human) | Lung cancer metastasis-related protein 1,Mediator complex subunit 19 |
| 48 | n | Mediator of RNA polymerase II transcription subunit 21 | polymer | 144 | 15575.2 | 1 | UniProt (Q13503) Pfam (PF11221) In PDB | Homo sapiens (Human) | Mediator complex subunit 21,RNA polymerase II holoenzyme component SRB7,RNAPII complex component SRB7,hSrb7 |
| 49 | o | Mediator of RNA polymerase II transcription subunit 31 | polymer | 131 | 15826.1 | 1 | UniProt (Q9Y3C7) Pfam (PF05669) In PDB | Homo sapiens (Human) | Mediator complex subunit 31,Mediator complex subunit SOH1,hSOH1 |
| 50 | p | Mediator of RNA polymerase II transcription subunit 27 | polymer | 311 | 35478.7 | 1 | UniProt (Q6P2C8) Pfam (PF11571) In PDB | Homo sapiens (Human) | Cofactor required for Sp1 transcriptional activation subunit 8,CRSP complex subunit 8,Mediator complex subunit 27,P37 TRAP/SMCC/PC2 subunit,Transcriptional coactivator CRSP34 |
| 51 | q | Mediator of RNA polymerase II transcription subunit 28 | polymer | 178 | 19540.1 | 1 | UniProt (Q9H204) Pfam (PF11594) In PDB | Homo sapiens (Human) | Endothelial-derived protein 1,Mediator complex subunit 28,Merlin and Grb2-interacting cytoskeletal protein,Magicin,Tumor angiogenesis marker EG-1 |
| 52 | r | unassigned peptide (MED29 or MED30) | polymer | 20 | 1720.1 | 1 | Homo sapiens (Human) | ||
| 53 | s | Mediator of RNA polymerase II transcription subunit 30 | polymer | 178 | 20301.2 | 1 | UniProt (Q96HR3) Pfam (PF11315) In PDB | Homo sapiens (Human) | Mediator complex subunit 30,TRAP/Mediator complex component TRAP25,Thyroid hormone receptor-associated protein 6,Thyroid hormone receptor-associated protein complex 25 kDa component,Trap25 |
| 54 | v | unassigned peptide (MED14) | polymer | 22 | 1890.3 | 1 | Homo sapiens (Human) | ||
| 55 | w | unassigned peptide (MED6) | polymer | 16 | 1379.7 | 1 | Homo sapiens (Human) | ||
| 56 | x | unassigned peptide (MED17) | polymer | 11 | 954.2 | 1 | Homo sapiens (Human) | ||
| 57 | y | unassigned peptide (MED29 or MED30) | polymer | 18 | 1549.9 | 1 | Trichoplusia ni | ||
| 58 | z | unassigned peptide (MED29 or MED30) | polymer | 23 | 1975.4 | 1 | Trichoplusia ni | ||
| 59 | 0 | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 1 | Chemie (SF4) | |||
| 60 | 3, 4, 6, A, B... | ZINC ION | non-polymer | 65.4 | 18 | Chemie (ZN) | |||
| 61 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 58 |
| Total formula weight | 1976948.8 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 1553.3 | |
| All* | Total formula weight | 1978502.1 |
