7NTI
Structure of TAK1 in complex with compound 22
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 7,TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | polymer | 315 | 35520.9 | 1 | UniProt (O43318) UniProt (Q15750) Pfam (PF07714) | Homo sapiens (Human) | Transforming growth factor-beta-activated kinase 1,TGF-beta-activated kinase 1,Mitogen-activated protein kinase 7-interacting protein 1,TGF-beta-activated kinase 1-binding protein 1,TAK1-binding protein 1 |
| 2 | B, C, D, E, F (A) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 3 | G, H (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 4 | I (A) | ~{N}-[[2-[bis(fluoranyl)methoxy]phenyl]methyl]-~{N}-[2-(methylamino)-2-oxidanylidene-ethyl]-2-pyrrolidin-1-ylcarbonyl-1~{H}-imidazole-4-carboxamide | non-polymer | 435.4 | 1 | Chemie (UWZ) | |||
| 5 | J (A) | water | water | 18.0 | 84 | Chemie (HOH) |
Sequence modifications
A: 31 - 303 (UniProt: O43318)
A: 468 - 504 (UniProt: Q15750)
| PDB | External Database | Details |
|---|---|---|
| Gly 26 | - | expression tag |
| Ser 27 | - | expression tag |
| Leu 28 | - | expression tag |
| His 29 | - | expression tag |
| Met 30 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35520.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1052.2 | |
| All* | Total formula weight | 36573.1 |
