Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 1001 |
| Chain | Residue |
| A | ARG289 |
| A | LEU490 |
| A | VAL493 |
| A | ASP494 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 1002 |
| Chain | Residue |
| A | THR169 |
| A | ALA294 |
| A | HOH1119 |
| A | HOH1127 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 1003 |
| Chain | Residue |
| A | SER146 |
| A | MET147 |
| A | TYR143 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 1004 |
| Chain | Residue |
| A | HIS86 |
| A | GLN139 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 1005 |
| Chain | Residue |
| A | ARG265 |
| A | SER272 |
| A | GLN273 |
| A | GLU279 |
| A | PRO292 |
| A | HOH1118 |
| A | HOH1131 |
| A | HOH1142 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 1006 |
| Chain | Residue |
| A | PRO121 |
| A | LEU122 |
| A | PRO123 |
| A | GLN299 |
| A | PRO301 |
| A | HIS495 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 1007 |
| Chain | Residue |
| A | PHE487 |
| A | TRP491 |
| A | HOH1155 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | binding site for residue UWZ A 1008 |
| Chain | Residue |
| A | VAL42 |
| A | GLU105 |
| A | TYR106 |
| A | ALA107 |
| A | GLY109 |
| A | GLY110 |
| A | SER111 |
| A | PRO160 |
| A | ASN161 |
| A | LEU162 |
| A | LEU163 |
| A | CYS174 |
| A | HOH1114 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 22 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGAFGVVCkAkwrakd............VAIK |
| Chain | Residue | Details |
| A | VAL42-LYS63 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiHrDLKppNLLL |
| Chain | Residue | Details |
| A | LEU152-LEU164 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"10702308","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10838074","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22406003","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q62073","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Required for interaction with MAP3K7","evidences":[{"source":"PubMed","id":"11323434","evidenceCode":"ECO:0000269"}]} |
